Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14977743 | 0.92 | IMPDH2 (0.38) | CYP2C8KCNH2NAMPTCYP3A4MAPK14 | |
| SCHEMBL14977569 | 0.90 | MAPK14 (0.37) | CYP2C8KCNH2MAPK14ABL1 | |
| SCHEMBL14977707 | 0.90 | PPARG (0.39) | CYP2C8KCNH2CYP3A4MAPK14SMN1; SMN2 | |
| SCHEMBL14977606 | 0.89 | MAPK14 (0.41) | CYP2C8KCNH2NAMPTMAPK14ABL1 | |
| SCHEMBL14977604 | 0.88 | MAPK14 (0.36) | CYP2C8KCNH2MAPK14ABL1 | |
| SCHEMBL14977581 | 0.87 | MAPK14 (0.39) | CYP2C8KCNH2NAMPTCYP3A4MAPK14 | |
| SCHEMBL14977841 | 0.87 | MAPK14 (0.35) | MAPK14SMN1; SMN2ABL1 | |
| SCHEMBL14986306 | 0.86 | MAPK14 (0.37) | CYP2C8KCNH2NAMPTMAPK14ABL1 | |
| SCHEMBL14977313 | 0.86 | ABL1 (0.41) | NAMPTMAPK14ABL1 | |
| SCHEMBL14977778 | 0.86 | ROCK2 (0.39) | MAPK14ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013075173-A1 | COMPOUNDS FOR THE TREATMENT OF HCV | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2013-05-30 | — | — | WO | claimed |
| WO-2013075173-A1 | COMPOUNDS FOR THE TREATMENT OF HCV | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2013-05-30 | — | — | WO | disclosed |