Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14980643 | 0.89 | PLK1 (0.33) | USP2ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL14980668 | 0.87 | USP2 (0.38) | USP2BRD4BRPF1EP300CREBBP | |
| SCHEMBL14980658 | 0.82 | CYP1A2 (0.38) | BRD4BRPF1EP300CREBBPCYP1A2 | |
| SCHEMBL14981115 | 0.67 | NTRK1 (0.33) | — | |
| SCHEMBL14980641 | 0.67 | MEN1 (0.31) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL16366864 | 0.65 | CYP1A2 (0.31) | CYP1A2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL14981227 | 0.64 | POLB (0.32) | — | |
| SCHEMBL14980659 | 0.64 | ACHE (0.32) | CYP1A2ALDH1A1MEN1 | |
| SCHEMBL13174918 | 0.58 | ALDH1A1 (0.38) | KDM4EALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL24415030 | 0.58 | USP2 (0.42) | USP2BRD4BRPF1EP300CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411396-B1 | THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2013-05-29 | — | — | EP | disclosed |