Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CRHBP | P24387 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14980674 | 0.87 | MAPK8 (0.32) | MEN1LMNAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL13174918 | 0.83 | ALDH1A1 (0.38) | MEN1LMNAHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL18828282 | 0.76 | ALDH1A1 (0.31) | ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL14980659 | 0.72 | ACHE (0.32) | MEN1ALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL14981221 | 0.69 | MTNR1A (0.31) | — | |
| SCHEMBL14980658 | 0.69 | CYP1A2 (0.38) | MEN1HPGDKMT2ASMN1; SMN2MAPT | |
| SCHEMBL14981115 | 0.69 | NTRK1 (0.33) | RAB9A | |
| SCHEMBL14980671 | 0.67 | USP2 (0.37) | MEN1HPGDKMT2AMAPTALDH1A1 | |
| SCHEMBL14585671 | 0.66 | ADRA2A (0.36) | MEN1LMNAHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL14980643 | 0.65 | PLK1 (0.33) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411396-B1 | THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS SA (CH) | 2013-05-29 | — | — | EP | disclosed |