SCHEMBL1499360

SCHEMBL1499360

CCS(=O)(=O)c1[c]nccc1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PSIP1 O75475 2/20 0.39
COMT P21964 1/20 0.37
GAA P10253 2/20 0.31
ADRA2A P08913 1/20 0.31
ADRA2C P18825 1/20 0.31
ADRA1D P25100 1/20 0.31
ADRA1A P35348 1/20 0.31
ADRA1B P35368 1/20 0.31
KDM4E B2RXH2 1/20 0.30
MAPT P10636 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
APOBEC3G Q9HC16 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1499166 0.79 ALOX15 (0.33)
SCHEMBL2067057 0.78 ALDH1A1 (0.45) KDM4EMAPT
SCHEMBL8131529 0.75 NAPRT (0.41) COMTKDM4EMAPTTDP1
SCHEMBL6280841 0.74
SCHEMBL17291116 0.72 PSIP1 (0.46) PSIP1COMTGAA
SCHEMBL7988077 0.71 ALDH1A1 (0.32)
SCHEMBL1599337 0.71 HTR6 (0.48) KDM4ETDP1
SCHEMBL16793419 0.71 ALDH1A1 (0.35) GAAADRA1ATDP1
SCHEMBL10332272 0.70 NR1I2 (0.36) KDM4ENPSR1
SCHEMBL16792380 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8299262-B2 Pyridylmethyl-sulfonamide compounds BASF SE (DE) 2012-10-30 US claimed
JP-2011506281-A 2011-03-03 JP claimed
EP-2262794-A1 SULFONAMIDE COMPOUNDS AND THEIR USE AS FUNGICIDE BASF SE (DE) 2010-12-22 EP claimed
US-20100317516-A1 Sulfonamide Compounds And Their Use As Fungicide BASF SE (DE) 2010-12-16 US claimed
US-20100249077-A1 Pyridylmethyl-Sulfonamide Compounds BASF SE (DE) 2010-09-30 US claimed
EP-2231605-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2010-09-29 EP claimed
WO-2009103650-A1 SULFONAMIDE COMPOUNDS AND THEIR USE AS FUNGICIDE BASF SE (DE) 2009-08-27 WO claimed
WO-2009071449-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2009-06-11 WO claimed
WO-2009071448-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2009-06-11 WO claimed
US-6225260-B1 USE OF SUCH COMPOUNDS AS PESTICIDES, HERBICIDES, FUNGICIDES, AND PLANT GROWTH REGULATING AGENTS. LONZA INC. 2001-05-01 US claimed
EP-0557308-B2 SYNERGISTIC HERBICIDAL AGENT AVENTIS CROPSCIENCE GMBH (DE) 2001-03-28 EP claimed
US-6143694-A AIDING RIPENING OF TOBACCO PLANT BY PREHARVEST APPLICATION OF NON-PHYTOTOXIC AMOUNT OF 2-(4,5-DIHYDRO-4-METHYL-4-(1-METHYLETHYL)-5-OXO-1H-IMIDAZOL-2 -YL)ARYLCARBOXYLATE TAYLOR JOHN B (US) 2000-11-07 US claimed
US-5886176-A Process for preparing sulphonylurea salts BAYER AKTIENGESELLSCHAFT (DE) 1999-03-23 US claimed
EP-0557308-B1 SYNERGISTIC HERBICIDAL AGENT HOECHST SCHERING AGREVO GMBH (DE) 1998-03-04 EP claimed
US-5599769-A Synergistic herbicidal compositions comprising glyphosate or glufosinate in combination with a sulfonylurea herbicide HOECHST AKTIENGESELLSCHAFT (DE) 1997-02-04 US claimed
EP-0559044-A1 Process for the preparation of sulfonylurea salts BAYER AG (DE) 1993-09-08 EP claimed
EP-0557308-A1 SYNERGISTIC HERBICIDAL AGENT Hoechst Schering AgrEvo GmbH (DE) 1993-09-01 EP claimed
WO-1992008353-A1 SYNERGISTIC HERBICIDAL AGENT HOECHST AKTIENGESELLSCHAFT (DE) 1992-05-29 WO claimed
US-8299262-B2 Pyridylmethyl-sulfonamide compounds BASF SE (DE) 2012-10-30 US disclosed
WO-1991006541-A1 SULPHONATED HETEROCYCLIC CARBOXAMIDES AS HERBICIDES, GROWTH REGULATORS OR FUNGICIDES HOECHST AKTIENGESELLSCHAFT (DE) 1991-05-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100317516-A1 Sulfonamide Compounds And Their Use As Fungicide STS, ARSA, CYP4X1 PSIP1 3234/4885COMT 4359/4885GAA 1886/4885
US-20100249077-A1 Pyridylmethyl-Sulfonamide Compounds CBR3, CBR1, CBS PSIP1 2174/4885COMT 4344/4885GAA 4442/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.