SCHEMBL1499422

SCHEMBL1499422

Clc1cccc(CCC2CO2)c1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 5/20 0.57
PNMT P11086 2/20 0.46
AOC3 Q16853 1/20 0.45
HTR3E A5X5Y0 1/20 0.45
HTR3B O95264 1/20 0.45
HTR3A P46098 1/20 0.45
HTR3D Q70Z44 1/20 0.45
HTR3C Q8WXA8 1/20 0.45
SIGMAR1 Q99720 1/20 0.42
CYP3A4 P08684 2/20 0.42
IDO1 P14902 2/20 0.42
AGXT P21549 2/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
CHRM2 P08172 1/20 0.41
CHRM1 P11229 1/20 0.41
CHRM3 P20309 1/20 0.41
C3AR1 Q16581 1/20 0.41
DRD4 P21917 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29432882 1.00 TAAR1 (0.57) TAAR1PNMTAOC3HTR3EHTR3B
SCHEMBL2514751 0.89 TAAR1 (0.49) TAAR1PNMTAOC3HTR3EHTR3B
SCHEMBL7051578 0.81 PNMT (0.48) TAAR1PNMTHTR3EHTR3BHTR3A
SCHEMBL8488289 0.79 MAOA (0.53) TAAR1SIGMAR1MEN1KMT2A
SCHEMBL3061311 0.79 TAAR1 (0.52) TAAR1IDO1MEN1KMT2A
SCHEMBL8804583 0.77 DRD4 (0.51) TAAR1AOC3CYP3A4IDO1MEN1
SCHEMBL24137898 0.77 MEN1 (0.62) TAAR1CYP3A4MEN1KMT2ADRD4
SCHEMBL2077308 0.77 MEN1 (0.62) TAAR1CYP3A4MEN1KMT2ADRD4
SCHEMBL52143 0.77 MEN1 (0.62) TAAR1CYP3A4MEN1KMT2ADRD4
SCHEMBL12050856 0.76 TAAR1 (0.74) TAAR1PNMTAOC3HTR3EHTR3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3710159-A1 CATALYST COMPONENTS FOR PROPYLENE POLYMERIZATION W. R. Grace & Co. - Conn. (US) 2020-09-23 EP claimed
US-8344079-B2 Molar ratio modifications to larger polyolefin catalysts BASF CORPORATION (US) 2013-01-01 US claimed
JP-2011508053-A 2011-03-10 JP claimed
EP-2242776-A1 MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS BASF Corporation (US) 2010-10-27 EP claimed
WO-2009088596-A1 MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS BASF CATALYSTS LLC (US) 2009-07-16 WO claimed
US-20090171044-A1 MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS BASF CATALYSTS LLC (US) 2009-07-02 US claimed
US-20260103548-A1 PROCESS FOR PRODUCING POLYPROPYLENE-ETHYLENE RANDOM COPOLYMER RESIN WITH SUSTAINABLE REACTOR OPERABILITY W. R. GRACE & CO.-CONN. 2026-04-16 US disclosed
EP-3592783-B1 ELECTRON DONORS FOR ZIEGLER-NATTA PRECATALYST PREPARATION AND CATALYST SYSTEM FOR OLEFIN POLYMERIZATION GRACE W R & CO (US) 2025-11-12 EP disclosed
US-20250235842-A1 GAS-PHASE PROCESS FOR MAKING POLYPROPYLENE RANDOM COPOLYMERS W.R. GRACE & CO.-CONN (US) 2025-07-24 US disclosed
US-20250145745-A1 HIGH MFR POLYPROPYLENE FOR MELTBLOWN NONWOVEN APPLICATIONS W. R. GRACE & CO.-CONN. 2025-05-08 US disclosed
US-20250109220-A1 Olefin Polymerization Catalyst Comprising Magnesium, Titanium, an Epoxy Compound and an Internal Electron Donor, Such as a 1,2-Phenylene Dibenzoate-Based Compound W. R. GRACE & CO.-CONN. 2025-04-03 US disclosed
US-12240925-B2 Process for preparing solid catalyst components for olefin polymerization W. R. GRACE & CO.- CONN. (US) 2025-03-04 US disclosed
US-20240392047-A1 CATALYST COMPONENT FOR PROPYLENE POLYMERIZATION WITH IMPROVED CATALYST PERFORMANCE W.R. GRACE & CO.-CONN (US) 2024-11-28 US disclosed
US-5672504-A TREATING MIXED EPOXIDE ENANTIOMORPHS WITH MICROORGANISMS TO INCREASE CONCENTRATION OF OPTICALLY PURE S-ENANTIOMORPHS DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1997-09-30 US disclosed
US-5466838-A Catalytic reaction of olefin with oxygen in the presence of aldehyde SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-11-14 US disclosed
EP-0540009-B1 Process for producing epoxides SUMITOMO CHEMICAL CO (JP) 1995-08-30 EP disclosed
US-5367087-A Process for producing epoxide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-11-22 US disclosed
EP-0611826-A2 Processes for production of optically active epoxides DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1994-08-24 EP disclosed
EP-0540009-A1 Process for producing epoxides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-05-05 EP disclosed
US-4309441-A HYPOTENSIVE AGENTS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1982-01-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12240925-B2 Process for preparing solid catalyst components for olefin polymerization POF1B, PPOX, OGFOD1 TAAR1 3916/4885PNMT 2407/4885AOC3 2517/4885
US-20260103548-A1 PROCESS FOR PRODUCING POLYPROPYLENE-ETHYLENE RANDOM COPOLYMER RESIN WITH SUSTAINABLE REACTOR OPERABILITY CCT4, PTGER1, TCP1 TAAR1 1463/4885PNMT 1317/4885AOC3 1619/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.