SCHEMBL149980

SCHEMBL149980

C=CC(=O)c1ccc2ccccc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 1.00
MEN1 O00255 2/20 1.00
ALDH1A1 P00352 2/20 1.00
CYP3A4 P08684 2/20 1.00
MAPT P10636 2/20 1.00
KMT2A Q03164 2/20 1.00
EGFR P00533 1/20 1.00
TP53 P04637 1/20 1.00
PKM P14618 1/20 1.00
HPGD P15428 1/20 1.00
ALOX15 P16050 1/20 1.00
ALOX12 P18054 1/20 1.00
JAK1 P23458 1/20 1.00
MAPK1 P28482 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
HSD17B10 Q99714 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
CES2 O00748 1/20 0.61
CES1 P23141 1/20 0.61
CYP1B1 Q16678 3/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29707545 1.00 KDM4E (1.00) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL30827199 1.00 KDM4E (1.00) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL3557840 0.94 KDM4E (0.89) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL13563344 0.90 MEN1 (0.81) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL1697544 0.82 ALDH1A1 (0.69) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL29884110 0.82 ALDH1A1 (0.69) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL9575208 0.81 KDM4E (0.68) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL13070473 0.81 MEN1 (0.68) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL9812510 0.81 MEN1 (0.68) KDM4EMEN1ALDH1A1CYP3A4MAPT
SCHEMBL13518256 0.81 ALDH1A1 (0.68) KDM4EMEN1ALDH1A1CYP3A4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 404 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111233645-A Method for preparing tri-substituted cyclopentene by MBH/Wittig domino reaction of vinylon insertion 浙江大学 2020-06-05 CN claimed
EP-2879675-B1 COMPOUNDS AND METHODS FOR TARGETING HSP90 UNIV DUKE (US) 2019-11-13 EP claimed
US-20180186885-A1 FZD7 SPECIFIC ANTIBODIES AND VACCINES TO TREAT CANCER AND CONTROL STEM CELL FUNCTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2018-07-05 US claimed
WO-2016205551-A2 FZD7 SPECIFIC ANTIBODIES AND VACCINES TO TREAT CANCER AND CONTROL STEM CELL FUNCTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-12-22 WO claimed
WO-2016205566-A1 FZD7 SPECIFIC ANTIBODIES AND VACCINES TO TREAT CANCER AND CONTROL STEM CELL FUNCTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-12-22 WO claimed
EP-2494865-A2 GUT FLORA-DERIVED EXTRACELLULAR VESICLES, AND METHOD FOR SEARCHING FOR A DISEASE MODEL, VACCINE, AND CANDIDATE DRUG AND FOR DIAGNOSIS USING SAME Aeon Medix Inc. (KR) 2012-09-05 EP claimed
WO-2011027971-A2 GUT FLORA-DERIVED EXTRACELLULAR VESICLES, AND METHOD FOR SEARCHING FOR A DISEASE MODEL, VACCINE, AND CANDIDATE DRUG AND FOR DIAGNOSIS USING SAME 주식회사이언메딕스 (KR) 2011-03-10 WO claimed
JP-2011506455-A 2011-03-03 JP claimed
US-20100272717-A1 COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER NOVARTIS AG (CH) 2010-10-28 US claimed
EP-2231147-A2 COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER Novartis AG (CH) 2010-09-29 EP claimed
WO-2009076170-A2 COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER NOVARTIS AG (CH) 2009-06-18 WO claimed
US-12616733-B2 XBP1, CD138, and CS1 peptides, pharmaceutical compositions that include the peptides, and methods of using such peptides and compositions DANA-FARBER CANCER INSTITUTE, INC. (US) 2026-05-05 US disclosed
US-20260041767-A1 METHODS OF IMPROVING CELLULAR THERAPY WITH ORGANELLE COMPLEXES UNIV HOKKAIDO NAT UNIV CORP (JP) 2026-02-12 US disclosed
US-20250312347-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS BROWN DENNIS M (US) 2025-10-09 US disclosed
US-20250290915-A1 METHOD FOR PREDICTING RESPONSIVENESS TO THERAPY Cancertain Limited (GB) 2025-09-18 US disclosed
EP-1207162-B1 7a-alkoxy-4H-pyrano-[3,2-d]-oxazol-2(3H)-one and process for producing the same UBE INDUSTRIES (JP) 2004-02-25 EP disclosed
US-20020072612-A1 7a-alkoxy-4H-pyrano [3,2-d] -oxazol-2 (3H) -one and process for producing the same UBE INDUSTRIES, LTD. (JP) 2002-06-13 US disclosed
EP-1207162-A1 7a-alkoxy-4H-pyrano-[3,2-d]-oxazol-2(3H)-one and process for producing the same Ube Industries, Ltd. (JP) 2002-05-22 EP disclosed
US-4035395-A Process for the preparation of ketones BAYER AKTIENGESELLSCHAFT (DT) 1977-07-12 US disclosed
US-4014889-A Process for preparing ketones BAYER AKTIENGESELLSCHAFT (DT) 1977-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250312347-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS UNG, DPYD, TPMT KDM4E 714/4885MEN1 2187/4885ALDH1A1 379/4885
US-20260041767-A1 METHODS OF IMPROVING CELLULAR THERAPY WITH ORGANELLE COMPLEXES TFAM, FIS1, TUFM KDM4E 2587/4885MEN1 3840/4885ALDH1A1 4231/4885
US-20020072612-A1 7a-alkoxy-4H-pyrano [3,2-d] -oxazol-2 (3H) -one and process for producing the same ACSL1, ACSL4, ACSL3 KDM4E 2201/4885MEN1 4677/4885ALDH1A1 11/4885
US-20100272717-A1 COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER ANXA5, BAX, ANXA6 KDM4E 1024/4885MEN1 2299/4885ALDH1A1 247/4885
US-12616733-B2 XBP1, CD138, and CS1 peptides, pharmaceutical compositions that include the peptides, and methods of using such peptides and compositions XBP1, MCL1, CD81 KDM4E 955/4885MEN1 2034/4885ALDH1A1 4207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.