Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15919625 | 0.83 | GAA (0.50) | MEN1KMT2ARAPGEF4ALDH1A1HTT | |
| SCHEMBL15176963 | 0.79 | NOX1 (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL15087203 | 0.79 | MAPT (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL27662278 | 0.79 | MAP2K2 (0.39) | SMN1; SMN2MEN1KMT2ARAPGEF4HDAC1 | |
| SCHEMBL31527731 | 0.78 | MAPT (0.41) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL31527687 | 0.78 | NOX1 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL31527801 | 0.78 | RAB9A (0.45) | SMN1; SMN2MEN1KMT2AALDH1A1HTT | |
| SCHEMBL28218285 | 0.76 | ACHE (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL15087313 | 0.75 | LOXL2 (0.33) | SMN1; SMN2MEN1KMT2ARAPGEF4ALDH1A1 | |
| SCHEMBL31527681 | 0.75 | GAA (0.51) | MEN1KMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148408-A1 | DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2018-05-31 | — | — | US | disclosed |
| US-8961621-B2 | Azo dyes | HUNTSMAN INTERNATIONAL LLC (US) | 2015-02-24 | — | — | US | disclosed |
| EP-2791249-A2 | AZO DYES | Huntsman Advanced Materials (Switzerland) GmbH (CH) | 2014-10-22 | — | — | EP | disclosed |
| US-20140304926-A1 | Azo Dyes | HUNTSMAN INTERNATIONAL LLC | 2014-10-16 | — | — | US | disclosed |
| US-20140256767-A1 | DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS | THE BROAD INSTITUTE, INC. (US) | 2014-09-11 | — | — | US | disclosed |
| WO-2013087400-A2 | AZO DYES | HUNTSMAN ADVANCED MATERIALS (SWITZERLAND) GMBH (CH) | 2013-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148408-A1 | DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS | KEAP1, NFE2L2, HMOX1 | SMN1; SMN2 2916/4885MEN1 4000/4885KMT2A 2469/4885 |
| US-20140256767-A1 | DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS | KEAP1, NFE2L2, HMOX1 | SMN1; SMN2 2916/4885MEN1 4000/4885KMT2A 2469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.