SCHEMBL15027504

SCHEMBL15027504

CCOC(=O)CC(CN(C)C)N(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGAM O43451 1/20 0.41
GAA P10253 1/20 0.41
SI P14410 1/20 0.41
MGAM2 Q2M2H8 1/20 0.41
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
ALDH1A1 P00352 7/20 0.39
TRPA1 O75762 1/20 0.39
ALOX15 P16050 3/20 0.37
CYP3A4 P08684 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
TSHR P16473 2/20 0.37
HSD17B10 Q99714 2/20 0.36
CHRM1 P11229 1/20 0.36
ADORA1 P30542 1/20 0.36
CYP1A2 P05177 1/20 0.34
LMNA P02545 1/20 0.33
CYP2D6 P10635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18995463 0.85 DNM1 (0.38) ALDH1A1TSHRCHRM1L3MBTL1CHRNB2
SCHEMBL3910325 0.84 MGAM (0.44) MGAMGAASIMGAM2CA12
SCHEMBL10081285 0.81 PRKCA (0.37) GAAALDH1A1TDP1TSHRL3MBTL1
SCHEMBL24489251 0.81 NAAA (0.49) ALDH1A1TSHRL3MBTL1
SCHEMBL19034578 0.81 MAPT (0.36) CHRNB2CHRNA4
SCHEMBL10084981 0.80 MEN1 (0.38) MGAMGAASIMGAM2TDP1
SCHEMBL24368308 0.79 GPR88 (0.35) ALDH1A1CYP3A4TDP1TSHRLMNA
SCHEMBL25935745 0.78 GAA (0.43) MGAMGAASIMGAM2CA12
SCHEMBL19242303 0.77 CYP3A4 (0.45) CA2ALDH1A1CYP3A4TDP1TSHR
SCHEMBL10081268 0.77 LMNA (0.36) TDP1TSHRLMNACYP2D6CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4218722-A2 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS Alnylam Pharmaceuticals, Inc. (US) 2023-08-02 EP disclosed
EP-3860561-B1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS INC (US) 2023-06-21 EP disclosed
EP-2788316-B1 BRANCHED ALKYL AND CYCLOALKYL TERMINATED BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS INC (US) 2019-04-24 EP disclosed
US-20170233734-A1 NUCLEIC ACID LIPID PARTICLE FORMULATIONS ALNYLAM PHARMACEUTICALS INC (US) 2017-08-17 US disclosed
US-9687448-B2 Nucleic acid lipid particle formulations ALNYLAM PHARMACEUTICALS, INC. (US) 2017-06-27 US disclosed
US-9682922-B2 Biodegradable lipids for the delivery of active agents ALNYLAM PHARMACEUTICALS, INC. (US) 2017-06-20 US disclosed
EP-2575764-B1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS INC (US) 2017-04-19 EP disclosed
US-9463247-B2 Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents ALNYLAM PHARMACEUTICALS, INC. (US) 2016-10-11 US disclosed
US-20160009637-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS BANK OF AMERICA, N.A. 2016-01-14 US disclosed
US-20150306039-A1 IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS BANK OF AMERICA, N.A. 2015-10-29 US disclosed
US-20150273068-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS BANK OF AMERICA, N.A. 2015-10-01 US disclosed
US-9061063-B2 Biodegradable lipids for the delivery of active agents ALNYLAM PHARMACEUTICALS, INC. (US) 2015-06-23 US disclosed
US-9012498-B2 Biodegradable lipids for the delivery of active agents ALNYLAM PHARMACEUTICALS, INC. (US) 2015-04-21 US disclosed
US-20150005363-A1 Branched Alkyl And Cycloalkyl Terminated Biodegradable Lipids For The Delivery Of Active Agents BANK OF AMERICA, N.A. 2015-01-01 US disclosed
WO-2014089239-A1 IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS ALNYLAM PHARMACEUTICALS, INC. (US) 2014-06-12 WO disclosed
US-20130195920-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS, INC. (US) 2013-08-01 US disclosed
WO-2013086354-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS, INC. (US) 2013-06-13 WO disclosed
WO-2013086322-A1 BRANCHED ALKYL AND CYCLOALKYL TERMINATED BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS, INC. (US) 2013-06-13 WO disclosed
WO-2011153493-A2 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS ALNYLAM PHARMACEUTICALS, INC. (US) 2011-12-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150005363-A1 Branched Alkyl And Cycloalkyl Terminated Biodegradable Lipids For The Delivery Of Active Agents LIPA, CETP, APOB MGAM 2476/4885GAA 307/4885SI 547/4885
US-20160009637-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS LIPA, CETP, APOB MGAM 2499/4885GAA 311/4885SI 412/4885
US-20130195920-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS LIPA, APOB, CETP MGAM 2416/4885GAA 253/4885SI 603/4885
US-20150273068-A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS LIPA, APOB, CETP MGAM 2416/4885GAA 253/4885SI 603/4885
US-20170233734-A1 NUCLEIC ACID LIPID PARTICLE FORMULATIONS LIPA, ABHD16A, CETP MGAM 3752/4885GAA 617/4885SI 2193/4885
US-20150306039-A1 IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS LIPA, NPC1L1, CETP MGAM 3778/4885GAA 580/4885SI 2084/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.