Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17970204 | 0.82 | MAPT (0.34) | ROCK2MAPK1TDP1KCNH2 | |
| SCHEMBL15028487 | 0.82 | KLRK1 (0.47) | ROCK2HDAC4HDAC7HDAC5AOC3 | |
| SCHEMBL8273803 | 0.81 | ACLY (0.47) | KMT2A | |
| SCHEMBL558019 | 0.79 | HDAC3 (0.46) | ROCK2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL558020 | 0.79 | HDAC3 (0.46) | ROCK2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13710928 | 0.78 | HDAC3 (0.44) | ROCK2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29009204 | 0.76 | ROCK2 (0.46) | ROCK2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3218001 | 0.76 | CTSS (0.45) | KMT2AMAPK1 | |
| SCHEMBL4425970 | 0.76 | KMT2A (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL20459562 | 0.73 | DPP4 (0.48) | KMT2ADPP4AOC3KCNH2DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980838-B2 | Cyclized peptidomimetic small molecule inhibitors of the WDR5 and MLL1 interaction | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-03-17 | — | — | US | disclosed |
| US-20130150309-A1 | CYCLIZED PEPTIDOMIMETIC SMALL MOLECULE INHIBITORS OF THE WDR5 AND MLL1 INTERACTION | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150309-A1 | CYCLIZED PEPTIDOMIMETIC SMALL MOLECULE INHIBITORS OF THE WDR5 AND MLL1 INTERACTION | WDR5, WDR1, WDR77 | ROCK2 2946/4885HDAC3 326/4885HDAC4 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.