Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLRK1 | P26718 | 1/20 | 0.47 |
| ▸ | MICA | Q29983 | 1/20 | 0.47 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.47 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15028527 | 0.82 | ROCK2 (0.42) | ROCK2HDAC4HDAC7HDAC5AOC3 | |
| SCHEMBL17970204 | 0.82 | MAPT (0.34) | KLRK1MICARAET1LTSHRROCK2 | |
| SCHEMBL8273803 | 0.81 | ACLY (0.47) | KLRK1MICARAET1LTSHRACLY | |
| SCHEMBL7490455 | 0.79 | FFAR2 (0.49) | FFAR2TSHRROCK2BRD4HDAC4 | |
| SCHEMBL23716167 | 0.78 | FFAR2 (0.47) | FFAR2ROCK2BRD4HDAC4HDAC7 | |
| SCHEMBL1978300 | 0.77 | HDAC4 (0.52) | KLRK1MICARAET1LFFAR2TSHR | |
| SCHEMBL6203749 | 0.76 | MDM2 (0.50) | FFAR2TSHRROCK2BRD4HDAC4 | |
| SCHEMBL7615467 | 0.73 | ADRB2 (0.45) | KLRK1MICARAET1LFFAR2TSHR | |
| SCHEMBL18901168 | 0.72 | ROCK2 (0.42) | TSHRROCK2ACLYAOC3 | |
| SCHEMBL12872520 | 0.72 | TSHR (0.53) | FFAR2TSHRROCK2BRD4HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980838-B2 | Cyclized peptidomimetic small molecule inhibitors of the WDR5 and MLL1 interaction | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-03-17 | — | — | US | disclosed |
| US-20130150309-A1 | CYCLIZED PEPTIDOMIMETIC SMALL MOLECULE INHIBITORS OF THE WDR5 AND MLL1 INTERACTION | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150309-A1 | CYCLIZED PEPTIDOMIMETIC SMALL MOLECULE INHIBITORS OF THE WDR5 AND MLL1 INTERACTION | WDR5, WDR1, WDR77 | KLRK1 4015/4885MICA 3431/4885RAET1L 604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.