Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | STAMBP | O95630 | 1/20 | 0.36 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | NNMT | P40261 | 2/20 | 0.35 |
| ▸ | PLK1 | P53350 | 2/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16465850 | 0.77 | BACE1 (0.40) | CDK8CDK19SYKNNMTLMNA | |
| SCHEMBL27386166 | 0.72 | ICAM1 (0.38) | SIRT2SIRT1SIRT3MKNK1MKNK2 | |
| SCHEMBL10093229 | 0.71 | PLAU (0.46) | PLK1 | |
| SCHEMBL28285907 | 0.71 | NNMT (0.41) | HPGDSPSMD14STAMBPCOPS5NNMT | |
| SCHEMBL30478243 | 0.71 | NNMT (0.41) | HPGDSPSMD14STAMBPCOPS5NNMT | |
| SCHEMBL3950709 | 0.69 | BAZ2B (0.49) | HPGDSMKNK1MKNK2PLK1BAZ2B | |
| SCHEMBL26755208 | 0.68 | PLK1 (0.44) | HPGDSSCN9ASCN2ASCN3ASCN10A | |
| SCHEMBL1503082 | 0.68 | HPGDS (0.51) | HPGDSMKNK1MKNK2NNMT | |
| SCHEMBL1503085 | 0.67 | NNMT (0.40) | HPGDSPSMD14STAMBPCOPS5MKNK1 | |
| SCHEMBL1503239 | 0.67 | KDM4E (0.45) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300433-A1 | HIV INTEGRASE INHIBITORS FROM PYRIDOXINE | Ambrilia Biopharma Inc. (CA) | 2011-03-30 | — | — | EP | disclosed |