Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7896439 | 0.76 | MMP1 (0.36) | GRIN1GRIN2AALDH1A1SMN1; SMN2OPRM1 | |
| SCHEMBL3020089 | 0.75 | L3MBTL1 (0.40) | GRIN1GRIN2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL15037437 | 0.72 | ALDH1A1 (0.50) | GRIN1GRIN2AALDH1A1GAAOPRM1 | |
| SCHEMBL15037440 | 0.72 | ALDH1A1 (0.40) | ALDH1A1GAASMN1; SMN2BACE1LMNA | |
| SCHEMBL13148284 | 0.71 | RAB9A (0.37) | SMN1; SMN2RAB9ALMNA | |
| SCHEMBL15037439 | 0.69 | ALDH1A1 (0.37) | ALDH1A1GAASMN1; SMN2SIGMAR1LMNA | |
| SCHEMBL19931803 | 0.69 | OPRM1 (0.50) | ALDH1A1GAASMN1; SMN2OPRM1DRD4 | |
| SCHEMBL13006991 | 0.68 | — | — | |
| SCHEMBL6439973 | 0.68 | OPRL1 (0.44) | ALDH1A1GAASMN1; SMN2OPRM1LMNA | |
| SCHEMBL6439975 | 0.68 | OPRL1 (0.44) | ALDH1A1GAASMN1; SMN2OPRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130158050-A1 | PIPERIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158050-A1 | PIPERIDINE DERIVATIVES | GRIN1, GRIN2A, GRIN2C | GRIN1 1/4885GRIN2A 2/4885ALDH1A1 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.