Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 known ✓ | Q07820 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.43 |
| ▸ | WNT3A | P56704 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665659 | 0.92 | ALDH1A1 (0.59) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| SCHEMBL4135291 | 0.82 | ALDH1A1 (0.57) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| SCHEMBL4132169 | 0.79 | ALDH1A1 (0.61) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| SCHEMBL4126015 | 0.78 | HPGD (0.60) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| SCHEMBL16419608 | 0.76 | ALDH1A1 (0.65) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL11663088 | 0.75 | HDAC1 (0.59) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL992300 | 0.74 | ALDH1A1 (0.67) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL994292 | 0.74 | ALDH1A1 (0.57) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL691269 | 0.74 | LMNA (0.57) | ALDH1A1LMNAMEN1KMT2ANPC1 | |
| SCHEMBL170394 | 0.73 | ALDH1A1 (0.69) | ALDH1A1LMNAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426116-B1 | Method for producing (S)-3-N-Methylamino-1-(2-thienyl)-1-propanol | SALTIGO GMBH (DE) | 2013-06-26 | — | — | EP | claimed |