Kumanon H

Kumanon H

SCHEMBL150578

CC(C)=CCc1c(O)ccc(C(=O)[C@@H]2[C@@H](c3c(O)cc(O)c4c(=O)c(CC=C(C)C)c(-c5ccc(O)cc5O)oc34)C=C(C)C[C@H]2c2ccc(O)cc2O)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 10/20 1.00
PTPN12 Q05209 4/20 1.00
PTPN22 Q9Y2R2 4/20 1.00
GUSB P08236 2/20 0.90
HIF1A Q16665 4/20 0.52
EPAS1 Q99814 4/20 0.52
PDE4D Q08499 3/20 0.52
PTGS1 P23219 2/20 0.52
BCHE P06276 1/20 0.52
ACHE P22303 1/20 0.52
BACE1 P56817 1/20 0.52
TYR P14679 1/20 0.48
PTGS2 P35354 1/20 0.47
PNLIP P16233 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Kumanon H SCHEMBL29541171 1.00 PTPN1 (1.00) PTPN1PTPN12PTPN22GUSBHIF1A
Kumanon H SCHEMBL29540653 1.00 PTPN1 (1.00) PTPN1PTPN12PTPN22GUSBHIF1A
Kumanon H SCHEMBL13233442 1.00 PTPN1 (1.00) PTPN1PTPN12PTPN22GUSBHIF1A
Kumanon H SCHEMBL30318001 1.00 PTPN1 (1.00) PTPN1PTPN12PTPN22GUSBHIF1A
Kumanon H SCHEMBL27014815 1.00 PTPN1 (1.00) PTPN1PTPN12PTPN22GUSBHIF1A
Kumanon H SCHEMBL30912100 1.00 PTPN1 (1.00) PTPN1PTPN12PTPN22GUSBHIF1A
Kumanon H SCHEMBL27013550 1.00 PTPN1 (1.00) PTPN1PTPN12PTPN22GUSBHIF1A
SCHEMBL13233441 0.97 PTPN1 (0.95) PTPN1PTPN12PTPN22GUSBHIF1A
Kumanon G SCHEMBL16362642 0.94 PTPN1 (1.00) PTPN1PTPN12PTPN22GUSBHIF1A
Kumanon G SCHEMBL20211451 0.94 PTPN1 (1.00) PTPN1PTPN12PTPN22GUSBHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083663-A1 BOTANICAL COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF ARKANSAS STATE UNIV JONESBORO (US) 2026-03-26 US claimed
WO-2024054685-A2 BOTANICAL COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF ARKANSAS STATE UNIVERSTIY-JONESBORO (US) 2024-03-14 WO claimed
CN-110075104-A Kuwanon H is preparing the application in osteosporosis resistant medicament 贵州大学 2019-08-02 CN claimed
CN-101836977-B Extract of mulberry and antibacterial application of Kuwanon H compound MEDICAL & PHARM IND TECH & DEV 2012-06-27 CN claimed
CN-101836977-A Extract of mulberry and antibacterial application of Kuwanon H compound MEDICAL & PHARM IND TECH & DEV 2010-09-22 CN claimed
CN-1107152-A Compound for inhibition of virus HIV of AIDS LUO SHIDE (CN) 1995-08-23 CN claimed
JP-56123979-A None JP disclosed
US-20260083663-A1 BOTANICAL COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF ARKANSAS STATE UNIV JONESBORO (US) 2026-03-26 US disclosed
CN-116751179-B New compound separated from white mulberry root-bark, preparation method and application thereof 成都乐美天医药科技有限公司 2025-04-04 CN disclosed
CN-119120351-A Application of plant polyphenol picrol H in regulating differentiation of intestinal organoids 中国科学院天津工业生物技术研究所 2024-12-13 CN disclosed
CN-119120351-A Application of plant polyphenol picrol H in regulating differentiation of intestinal organoids 中国科学院天津工业生物技术研究所 2024-12-13 CN disclosed
CN-119033875-A Antibacterial composition and application thereof 云南大学 2024-11-29 CN disclosed
US-12042523-B2 Compositions and methods for managing or improving bone disorders, joint disorders, cartilage disorders, or a combination thereof UNIGEN, INC. (US) 2024-07-23 US disclosed
US-20100166898-A1 ANTI-BACTERIAL USE OF EXTRACT FROM MORUS AUSTRALIS POIR. AND COMPOUND KUWANON H MEDICAL AND PHARMACEUTICAL INDUSTRY TECHNOLOGY AND DEVELOPMENT CENTER (TW) 2010-07-01 US disclosed
WO-2010060018-A1 AZO AND DIAZA DERIVATIVES AND USES THEREOF IN PHOTOTHERAPY MALLINCKRODT INC. (US) 2010-05-27 WO disclosed
JP-2007022957-A TGF-β RECEPTOR ANTAGONIST TSUMURA & CO 2007-02-01 JP disclosed
US-20060172020-A1 Dietary supplement for promoting control of blood-sugar levels and associated pathology in type 2 diabeties SANTE INTERNATIONAL, INC. 2006-08-03 US disclosed
WO-2005009351-A2 DIETARY SUPPLEMENT FOR PROMOTING CONTROL OF BLOOD-SUGAR LEVELS AND ASSOCIATED PATHOLOGY IN TYPE 2 DIABETICS Santé International, Inc. (US) 2005-02-03 WO disclosed
CN-1058609-C Compound for inhibition of virus HIV of AIDS LUO SHIDE (CN) 2000-11-22 CN disclosed
JP-S56123979-A NOVEL 8-SUBSTITUTED CYCLOHEXENYLFLAVONE DERIVATIVE OBTAINED FROM PLANT OF GENUS MORUS ZENYAKU KOGYO KK 1981-09-29 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100166898-A1 ANTI-BACTERIAL USE OF EXTRACT FROM MORUS AUSTRALIS POIR. AND COMPOUND KUWANON H SPOUT1, HK1, KCNH1 PTPN1 3456/4885PTPN12 2763/4885PTPN22 3556/4885
US-20260083663-A1 BOTANICAL COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF SAMM50, SYMPK, CD69 PTPN1 3495/4885PTPN12 3575/4885PTPN22 3732/4885
US-12042523-B2 Compositions and methods for managing or improving bone disorders, joint disorders, cartilage disorders, or a combination thereof MATR3, ACACA, COL2A1 PTPN1 4697/4885PTPN12 4639/4885PTPN22 4781/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.