SCHEMBL1506080

SCHEMBL1506080

c1ccc(C(OCCc2ccc(CN3CCCCC3)cc2)c2ccccc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.61
SLC6A3 Q01959 4/20 0.59
SLC6A2 P23975 3/20 0.59
SLC6A4 P31645 3/20 0.59
CYP3A4 P08684 2/20 0.59
CYP1A2 P05177 2/20 0.59
CYP2D6 P10635 2/20 0.59
TSHR P16473 2/20 0.59
CYP2C19 P33261 2/20 0.59
HIF1A Q16665 2/20 0.59
SLC22A1 O15245 1/20 0.59
CHRM2 P08172 1/20 0.59
HTR1A P08908 1/20 0.59
ADRA2A P08913 1/20 0.59
CHRM1 P11229 1/20 0.59
DRD1 P21728 1/20 0.59
TBXA2R P21731 1/20 0.59
ADRA1A P35348 1/20 0.59
OPRM1 P35372 1/20 0.59
DRD3 P35462 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Perastine SCHEMBL1506306 0.79 CYP3A4 (0.83) SIGMAR1SLC6A3SLC6A2SLC6A4CYP3A4
SCHEMBL28498638 0.78 SIGMAR1 (0.62) SIGMAR1SLC6A3SLC6A2SLC6A4CYP1A2
Perastine SCHEMBL29768269 0.77 CYP3A4 (0.83) SIGMAR1SLC6A3SLC6A2SLC6A4CYP3A4
SCHEMBL5175555 0.77 LTA4H (0.68) TSHR
SCHEMBL13958988 0.75 SIGMAR1 (0.79) SIGMAR1SLC6A3ADRA1A
Cloperastine SCHEMBL284715 0.74 SLC6A2 (1.00) SIGMAR1SLC6A3SLC6A2SLC6A4CYP3A4
Cloperastine SCHEMBL29617329 0.74 SLC6A2 (1.00) SIGMAR1SLC6A3SLC6A2SLC6A4CYP3A4
Cloperastine SCHEMBL9613613 0.74 SLC6A2 (1.00) SIGMAR1SLC6A3SLC6A2SLC6A4CYP3A4
SCHEMBL688047 0.74 SIGMAR1 (0.77) SIGMAR1SLC6A3CYP2D6CYP2C19SMN1; SMN2
SCHEMBL11141692 0.74 SIGMAR1 (0.77) SIGMAR1SLC6A3CYP2D6CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2291378-A2 N- AND O-SUBSTITUTED 4-Ý2-(DIPHENYLMETHOXY)-ETHYL¨-1-Ý(PHENYL)METHYL¨PIPERIDINE ANALOGS AND METHODS OF TREATING CNS DISORDERS THEREWITH WAYNE STATE UNIVERSITY (US) 2011-03-09 EP disclosed
WO-2009094428-A2 N- AND O-SUBSTITUTED 4-[2-(DIPHENYLMETHOXY)-ETHYL]-1-[(PHENYL)METHYL]PIPERIDINE ANALOGS AND METHODS OF TREATING CNS DISORDERS THEREWITH WAYNE STATE UNIVERSITY (US) 2009-07-30 WO disclosed
WO-2001098266-A2 N-AND O-SUBSTITUTED 4-[2-(DIPHENYLMETHOXY)-ETHYL]-1-[(PHENYL)METHYL]PIPERIDINE ANALOGS AND METHODS OF TREATING CNS DISORDERS THEREWITH WAYNE STATE UNIVERSITY (US) 2001-12-27 WO disclosed