SCHEMBL1506818

SCHEMBL1506818

OB(O)c1ccccc1CNCc1cccc2cc3ccccc3cc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MC5R P33032 2/20 0.47
MAPK1 P28482 1/20 0.47
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
MC1R Q01726 1/20 0.39
LIPG Q9Y5X9 1/20 0.38
CYP2D6 P10635 1/20 0.37
TSHR P16473 1/20 0.37
HIF1A Q16665 1/20 0.37
HPGD P15428 1/20 0.36
SMPD1 P17405 1/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
GAA P10253 2/20 0.36
CA2 P00918 1/20 0.36
MAPT P10636 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TERT O14746 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ATM Q13315 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13970784 0.85 MC5R (0.40) MC5RMAPK1KMT2AMEN1MC1R
Anthracene SCHEMBL1506819 0.79 LIPG (0.43) LIPGCYP2D6CA2SMN1; SMN2
SCHEMBL5870343 0.77 TERT (0.47) MC5RMAPK1KMT2AMEN1TSHR
SCHEMBL15112993 0.77 MC5R (0.38) MC5RMAPK1KMT2AMEN1MC1R
SCHEMBL28826754 0.76 MAPK1 (0.46) MC5RMAPK1KMT2AMEN1HPGD
SCHEMBL1506816 0.76 MAPT (0.36) KMT2AMEN1LIPGHPGDALDH1A1
SCHEMBL1506817 0.76 MAPT (0.39) MAPK1KMT2AMEN1LIPGKDM4E
SCHEMBL829841 0.76 ALDH1A1 (0.46) KMT2AMEN1HIF1AHPGDKDM4E
SCHEMBL26010250 0.75 PKM (0.50) MC5RMAPK1KMT2AMEN1LIPG
SCHEMBL3144929 0.75 IFNAR1 (0.51) MC5RMAPK1KMT2AMEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2292626-B1 Detection of analytes in aqueous environments SENSEONICS INC (US) 2014-05-21 EP claimed
EP-1307464-B1 DETECTION OF ANALYTES IN AQUEOUS ENVIRONMENTS SENSEONICS INC (US) 2013-02-13 EP claimed
US-7939332-B2 Detection of analytes in aqueous environments SENSORS FOR MEDICINE AND SCIENCE, INC. (US) 2011-05-10 US claimed
EP-2292626-A1 Detection of analytes in aqueous environments Sensors for Medicine and Science, Inc. (US) 2011-03-09 EP claimed
WO-2007011691-A2 IMPLANTABLE DEVICE FOR DETECTING AN ANALYTE IN VIVO SENSORS FOR MEDICINE AND SCIENCE, INC. (US) 2007-01-25 WO claimed
US-20070014726-A1 Oxidation-resistant indicator macromolecule SENSORS FOR MEDICINE AND SCIENCE (US) 2007-01-18 US claimed
US-20060281185-A1 Detection of analytes in aqueous environments SENSORS FOR MEDICINE AND SCIENCE, INC. (US) 2006-12-14 US claimed
US-7060503-B2 Detection of Analytes in aqueous environments SENSORS FOR MEDICINE AND SCIENCE, INC. (US) 2006-06-13 US claimed
EP-1557422-A2 Detection of analytes in aqueous environments Sensors for Medicine and Science, Inc. (US) 2005-07-27 EP claimed
US-20040229370-A1 Detection of analytes in aqueous environments SENSORS FOR MEDICINE AND SCIENCE, INC. (US) 2004-11-18 US claimed
US-6794195-B2 QUANTITATIVE, QUALITATIVE ANALYSIS SENSORS FOR MEDICINE & SCIENCE, INC. 2004-09-21 US claimed
EP-1307464-A1 DETECTION OF ANALYTES IN AQUEOUS ENVIRONMENTS Sensors for Medicine and Science, Inc. (US) 2003-05-07 EP claimed
US-20020039793-A1 Detection of analytes in aqueous environments SENSORS FOR MEDICINE AND SCIENCE, INC. 2002-04-04 US claimed
WO-2002012251-A1 DETECTION OF ANALYTES IN AQUEOUS ENVIRONMENTS SENSORS FOR MEDICINE AND SCIENCE, INC. (US) 2002-02-14 WO claimed
EP-1307464-B1 DETECTION OF ANALYTES IN AQUEOUS ENVIRONMENTS SENSEONICS INC (US) 2013-02-13 EP disclosed
EP-2292626-A1 Detection of analytes in aqueous environments Sensors for Medicine and Science, Inc. (US) 2011-03-09 EP disclosed
WO-2007011691-A3 IMPLANTABLE DEVICE FOR DETECTING AN ANALYTE IN VIVO SENSORS FOR MED & SCIENCE INC (US) 2007-03-15 WO disclosed
WO-2007011691-A2 IMPLANTABLE DEVICE FOR DETECTING AN ANALYTE IN VIVO SENSORS FOR MEDICINE AND SCIENCE, INC. (US) 2007-01-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070014726-A1 Oxidation-resistant indicator macromolecule MB, LPO, GPX4 MC5R 4509/4885MAPK1 1917/4885KMT2A 4038/4885
US-20060281185-A1 Detection of analytes in aqueous environments MPI, NEFM, CD44 MC5R 4568/4885MAPK1 3508/4885KMT2A 4837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.