Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALPG | P10696 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27788015 | 0.93 | NAAA (0.61) | SMN1; SMN2L3MBTL1NAAAESR1 | |
| SCHEMBL15682852 | 0.93 | NAAA (0.61) | SMN1; SMN2L3MBTL1NAAAESR1 | |
| SCHEMBL27788014 | 0.93 | NAAA (0.61) | SMN1; SMN2L3MBTL1NAAAESR1 | |
| SCHEMBL10933369 | 0.93 | NAAA (0.61) | SMN1; SMN2L3MBTL1NAAAESR1 | |
| SCHEMBL27766436 | 0.93 | NAAA (0.61) | SMN1; SMN2L3MBTL1NAAAESR1 | |
| SCHEMBL27924881 | 0.93 | NAAA (0.61) | SMN1; SMN2L3MBTL1NAAAESR1 | |
| SCHEMBL20206982 | 0.89 | KDM4E (0.57) | SMN1; SMN2HTTL3MBTL1KDM4ENSD2 | |
| SCHEMBL16784750 | 0.89 | KDM4E (0.61) | SMN1; SMN2HTTL3MBTL1KDM4ENSD2 | |
| SCHEMBL13286803 | 0.89 | KDM4E (0.61) | SMN1; SMN2HTTL3MBTL1KDM4ENSD2 | |
| SCHEMBL24871959 | 0.87 | KDM4E (0.59) | HTTL3MBTL1KDM4ENSD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544952-B1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIV ANTWERPEN (BE) | 2024-11-06 | — | — | EP | disclosed |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | UNIVERSITAIR ZIEKENHUIS ANTWERPEN (BE) | 2020-08-11 | — | — | US | disclosed |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | UNIVERSITAIR ZIEKENHUIS ANTWERPEN (BE) | 2020-08-11 | — | — | US | disclosed |
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2019-09-19 | — | — | US | disclosed |
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2019-09-19 | — | — | US | disclosed |
| WO-2018096088-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2018-05-31 | — | — | WO | disclosed |
| US-9517993-B2 | Antagonists of the toll-like receptor 1/2 complex | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-12-13 | — | — | US | disclosed |
| US-9517993-B2 | Antagonists of the toll-like receptor 1/2 complex | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-10 | — | — | US | disclosed |
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-10 | — | — | US | disclosed |
| EP-2879669-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | The Regents of The University of Colorado, A Body Corporate (US) | 2015-06-10 | — | — | EP | disclosed |
| WO-2014022287-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-02-06 | — | — | WO | disclosed |
| WO-2014022287-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-02-06 | — | — | WO | disclosed |
| US-20130164228-A1 | COMPOSITIONS COMPRISING GALLATES AND GALLAMIDES | COLGATE-PALMOLIVE COMPANY (US) | 2013-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130164228-A1 | COMPOSITIONS COMPRISING GALLATES AND GALLAMIDES | CUTA, PGC, GTF3C5 | SMN1; SMN2 4735/4885BCL2 1747/4885MCL1 2778/4885 |
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | ATG4B, ATG7, ATG4A | SMN1; SMN2 4724/4885BCL2 814/4885MCL1 1018/4885 |
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | TLR2, TLR1, TLR3 | SMN1; SMN2 2472/4885BCL2 1626/4885MCL1 4555/4885 |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | ATG4B, ATG7, BECN1 | SMN1; SMN2 4651/4885BCL2 707/4885MCL1 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.