Water

Water

SCHEMBL1507364

N[C@@H](Cc1cn(Cl)cn1)C(=O)O.O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 known ✓ P23219 1/20 0.40
GRIA1 known ✓ P42261 2/20 0.38
GRIA2 known ✓ P42262 2/20 0.38
GRIA3 known ✓ P42263 2/20 0.38
GRIA4 known ✓ P48058 2/20 0.38
MEN1 known ✓ O00255 1/20 0.37
THRB known ✓ P10828 1/20 0.37
CYP1A2 P05177 1/20 0.43
SLC7A5 Q01650 3/20 0.40
PKM P14618 2/20 0.40
SLC1A3 P43003 1/20 0.40
ALPI P09923 1/20 0.40
XIAP P98170 1/20 0.40
TYR P14679 5/20 0.39
CPB2 Q96IY4 3/20 0.37
HSD17B10 Q99714 2/20 0.37
CYP3A4 P08684 2/20 0.37
USP2 O75604 2/20 0.37
RGS12 O14924 1/20 0.37
CYP2C9 P11712 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL3639234 1.00 CYP1A2 (0.43) CYP1A2SLC7A5PKMSLC1A3ALPI
SCHEMBL503556 0.98 CYP1A2 (0.44) CYP1A2SLC7A5PKMSLC1A3ALPI
Histidine SCHEMBL5134200 0.83 CYP3A4 (0.67) SLC7A5CPB2CYP3A4HIF1A
SCHEMBL17224471 0.82 CYP1A2 (0.44) CYP1A2SLC7A5PKMSLC1A3ALPI
SCHEMBL358922 0.82 CYP1A2 (0.44) CYP1A2SLC7A5PKMSLC1A3ALPI
SCHEMBL27974517 0.81 CYP1A2 (0.46) CYP1A2SLC7A5PKMSLC1A3ALPI
Hydrochloric Acid SCHEMBL14831326 0.81 CYP1A2 (0.43) CYP1A2SLC7A5PKMSLC1A3ALPI
SCHEMBL4726518 0.80 CYP1A2 (0.45) CYP1A2SLC7A5PKMSLC1A3ALPI
SCHEMBL44187 0.80 CYP1A2 (0.45) CYP1A2SLC7A5PKMSLC1A3ALPI
SCHEMBL4727798 0.80 CYP1A2 (0.45) CYP1A2SLC7A5PKMSLC1A3ALPI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5252322-A Skin tanning compositions containing imidazoles THE GILLETTE COMPANY (US) 1993-10-12 US claimed
EP-4716693-A2 PHARMACEUTICAL COMPOSITIONS FOR ANTIBODIES AND MAKING AND USING THE SAME INVETX, INC. (US) 2026-04-01 EP disclosed
WO-2024243322-A9 PHARMACEUTICAL COMPOSITIONS FOR ANTIBODIES AND MAKING AND USING THE SAME INVETX, INC. (US) 2025-03-27 WO disclosed
US-20240392009-A1 PHARMACEUTICAL COMPOSITIONS FOR ANTIBODIES AND MAKING AND USING THE SAME INVETX INC (US) 2024-11-28 US disclosed
WO-2024243322-A2 PHARMACEUTICAL COMPOSITIONS FOR ANTIBODIES AND MAKING AND USING THE SAME INVETX, INC. (US) 2024-11-28 WO disclosed
WO-2024155803-A2 IgG Fc VARIANTS WITH REDUCED SELF-ASSOCIATION THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2024-07-25 WO disclosed
US-20230190930-A1 ANTI-NUCLEOLIN ANTIBODIES MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) 2023-06-22 US disclosed
US-11357849-B2 Anti-nucleolin antibodies MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) 2022-06-14 US disclosed
EP-2294150-B1 METHOD FOR DIRT-RESISTANT TREATMENT OF BANK NOTES AND/OR SECURITY PAPERS IN GENERAL FEDRIGONI SPA (IT) 2020-05-20 EP disclosed
US-20190338036-A1 ANTIBODY FORMULATIONS PRECISION DERMATOLOGY, INC. 2019-11-07 US disclosed
US-20080311119-A1 ANTIBODY FORMULATIONS BIOGEN IDEC MA INC. (US) 2008-12-18 US disclosed
EP-1853310-A2 ANTI A BETA ANTIBODY FORMULATION Elan Pharma International Limited (IE) 2007-11-14 EP disclosed
EP-1841456-A2 STABILIZED LIQUID POLYPEPTIDE FORMULATIONS Wyeth (US) 2007-10-10 EP disclosed
US-20060210557-A1 Stabilized liquid polypeptide formulations WYETH 2006-09-21 US disclosed
US-20060193850-A1 Anti a beta antibody formulation WYETH LLC 2006-08-31 US disclosed
WO-2006083689-A2 ANTI A BETA ANTIBODY FORMULATION ELAN PHARMA INTERNATIONAL LIMITED (IE) 2006-08-10 WO disclosed
WO-2006081587-A2 STABILIZED LIQUID POLYPEPTIDE FORMULATIONS WYETH (US) 2006-08-03 WO disclosed
EP-0673783-B1 Recording sheets containing purine, pyrimidine, benzimidazole, imidazolidine, urazole, pyrazole, triazole, benzotriazole, tetrazole, and pyrazine compounds XEROX CORP (US) 2000-07-05 EP disclosed
EP-0673783-A2 Recording sheets containing purine, pyrimidine, benzimidazole, imidazolidine, urazole, pyrazole, triazole, benzotriazole, tetrazole, and pyrazine compounds XEROX CORPORATION (US) 1995-09-27 EP disclosed
US-5252322-A Skin tanning compositions containing imidazoles THE GILLETTE COMPANY (US) 1993-10-12 US disclosed