Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16239239 | 0.91 | RAB9A (0.41) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL15084366 | 0.80 | HSD17B10 (0.40) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL17967300 | 0.79 | KMT2A (0.41) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL25663232 | 0.79 | NR4A2 (0.34) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL17928514 | 0.76 | TSHR (0.39) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL15913967 | 0.75 | RAB9A (0.39) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL19755569 | 0.75 | LMNA (0.44) | HSD17B10ALDH1A1HPGDTSHRCHRM1 | |
| SCHEMBL85857 | 0.73 | PDE10A (0.48) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL21120535 | 0.73 | HSD17B10 (0.38) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL18530919 | 0.72 | TSHR (0.39) | KDM4EHSD17B10ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170204117-A1 | PROCESS FOR PREPARING (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-METHOXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,- 12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE | VIIV HEALTHCARE COMPANY | 2017-07-20 | — | — | US | disclosed |
| US-9643981-B2 | Process for preparing (4R,12aS)-N-(2,4-difluorobenzyl)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12A-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | VIIV HEALTHCARE COMPANY (US) | 2017-05-09 | — | — | US | disclosed |
| US-20150329559-A1 | PROCESS FOR PREPARING (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-METHOXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE | VIIV HEALTHCARE COMPANY | 2015-11-19 | — | — | US | disclosed |
| US-9120817-B2 | Process for preparing (4R,12aS)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′ ,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid | VIIV HEALTHCARE COMPANY (US) | 2015-09-01 | — | — | US | disclosed |
| US-20150057444-A1 | Process for Preparing Pyridinone Carboxylic Acid Aldehydes | VIIV HEALTHCARE CO (US) | 2015-02-26 | — | — | US | disclosed |
| US-8889877-B2 | Processes for preparing pyridinone carboxylic acid aldehydes | VIIV HEALTHCARE COMPANY (US) | 2014-11-18 | — | — | US | disclosed |
| US-20130172551-A1 | Process for Preparing Carbamolypyridone Derivatives and Intermediates | VIIV HEALTHCARE COMPANY | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329559-A1 | PROCESS FOR PREPARING (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-METHOXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE | CYP4B1, CYP4X1, CYP4F12 | KDM4E 113/4885HSD17B10 2623/4885ALDH1A1 153/4885 |
| US-20170204117-A1 | PROCESS FOR PREPARING (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-METHOXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,- 12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE | CYP4B1, CYP4F12, CYP4X1 | KDM4E 44/4885HSD17B10 2360/4885ALDH1A1 186/4885 |
| US-20130172551-A1 | Process for Preparing Carbamolypyridone Derivatives and Intermediates | CPS1, CYP3A4, DHPS | KDM4E 633/4885HSD17B10 1957/4885ALDH1A1 2141/4885 |
| US-20150057444-A1 | Process for Preparing Pyridinone Carboxylic Acid Aldehydes | PLPBP, SDHA, DPYD | KDM4E 1313/4885HSD17B10 625/4885ALDH1A1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.