Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 4/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15095046 | 0.87 | MAPT (0.41) | MAOAMAOB | |
| SCHEMBL31680549 | 0.85 | MMP2 (0.54) | BRAF | |
| SCHEMBL21067860 | 0.84 | KMT2A (0.58) | — | |
| SCHEMBL15094744 | 0.84 | KMT2A (0.49) | RXFP1 | |
| SCHEMBL31125137 | 0.82 | MAPT (0.59) | — | |
| SCHEMBL21812212 | 0.82 | MAOA (0.54) | MAOAMAOB | |
| SCHEMBL15094666 | 0.81 | RAB9A (0.54) | RXFP1 | |
| SCHEMBL9589707 | 0.80 | NPC1 (0.49) | MAOAMAOB | |
| SCHEMBL1249670 | 0.80 | NPC1 (0.55) | RXFP1 | |
| SCHEMBL15094761 | 0.79 | BRAF (0.50) | BRAFMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604493-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2020-03-31 | — | — | US | disclosed |
| US-20170088524-A1 | Compositions, Methods of Use, And Methods of Treatment | UNIVERSITY OF SOUTH FLORIDA | 2017-03-30 | — | — | US | disclosed |
| US-9556131-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2017-01-31 | — | — | US | disclosed |
| US-20140378516-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF SOUTH FLORIDA | 2014-12-25 | — | — | US | disclosed |
| EP-2800568-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | University Of South Florida (US) | 2014-11-12 | — | — | EP | disclosed |
| WO-2013103760-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378516-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | LIPA, LCT, GAA | RXFP1 3847/4885MAPK14 4874/4885BRAF 3159/4885 |
| US-10604493-B2 | Compositions, methods of use, and methods of treatment | LIPA, LCT, GAA | RXFP1 3847/4885MAPK14 4874/4885BRAF 3159/4885 |
| US-20170088524-A1 | Compositions, Methods of Use, And Methods of Treatment | LIPA, LCT, GAA | RXFP1 3847/4885MAPK14 4874/4885BRAF 3159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.