Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15094744 | 0.90 | KMT2A (0.49) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL31680549 | 0.88 | MMP2 (0.54) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL1505455 | 0.87 | GABRG2 (0.50) | RAB9ATP53PLAUNPC1MAPT | |
| SCHEMBL21067860 | 0.85 | KMT2A (0.58) | RAB9ASMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL21812212 | 0.83 | MAOA (0.54) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL15094758 | 0.81 | RXFP1 (0.48) | RXFP1 | |
| SCHEMBL9589707 | 0.81 | NPC1 (0.49) | RAB9ASMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL21812214 | 0.81 | ROCK2 (0.47) | TP53MEN1KMT2ALMNAMAPT | |
| SCHEMBL1249670 | 0.81 | NPC1 (0.55) | RAB9ATP53MEN1KMT2APLAU | |
| SCHEMBL15094761 | 0.80 | BRAF (0.50) | RAB9AMEN1KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604493-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2020-03-31 | — | — | US | disclosed |
| US-20170088524-A1 | Compositions, Methods of Use, And Methods of Treatment | UNIVERSITY OF SOUTH FLORIDA | 2017-03-30 | — | — | US | disclosed |
| US-9556131-B2 | Compositions, methods of use, and methods of treatment | UNIVERSITY OF SOUTH FLORIDA (US) | 2017-01-31 | — | — | US | disclosed |
| US-20140378516-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF SOUTH FLORIDA | 2014-12-25 | — | — | US | disclosed |
| EP-2800568-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | University Of South Florida (US) | 2014-11-12 | — | — | EP | disclosed |
| WO-2013103760-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378516-A1 | COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT | LIPA, LCT, GAA | RAB9A 2492/4885SMN1; SMN2 789/4885TP53 2502/4885 |
| US-10604493-B2 | Compositions, methods of use, and methods of treatment | LIPA, LCT, GAA | RAB9A 2492/4885SMN1; SMN2 789/4885TP53 2502/4885 |
| US-20170088524-A1 | Compositions, Methods of Use, And Methods of Treatment | LIPA, LCT, GAA | RAB9A 2492/4885SMN1; SMN2 789/4885TP53 2502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.