SCHEMBL15210209

SCHEMBL15210209

c1ccc(OCn2cccn2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.46
TBXAS1 P24557 1/20 0.45
ALDH1A1 P00352 1/20 0.43
GABRA1 P14867 1/20 0.42
GABRG2 P18507 1/20 0.42
GABRB3 P28472 1/20 0.42
GABRA5 P31644 1/20 0.42
GABRA3 P34903 1/20 0.42
GABRA2 P47869 1/20 0.42
THRB P10828 1/20 0.40
KCNA3 P22001 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
NPC1 O15118 1/20 0.40
GLA P06280 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
LTA4H P09960 1/20 0.38
HTT P42858 1/20 0.37
KCNH2 Q12809 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9364210 0.93 LTA4H (0.50) TSHRTBXAS1ALDH1A1THRBNPC1
SCHEMBL5755407 0.84 THRB (0.38) TSHRTBXAS1ALDH1A1GABRA1GABRG2
SCHEMBL9021032 0.75 LTA4H (0.56) TSHRTBXAS1ALDH1A1MAPTNPC1
SCHEMBL202604 0.74 PARP1 (0.48) TBXAS1GAAMAPTNPC1RAB9A
SCHEMBL1563130 0.74 TSHR (0.48) TSHRALDH1A1GABRA1GABRG2GABRB3
SCHEMBL17384720 0.73 GRIN2B (0.36) ALDH1A1GABRA1GABRG2GABRB3GABRA5
SCHEMBL6003334 0.73 KCNA3 (0.48) TSHRTBXAS1ALDH1A1KCNA3LTA4H
SCHEMBL3067280 0.72 FDPS (0.41) TSHRGABRA1GABRG2GABRB3GABRA5
SCHEMBL2718879 0.72 LTA4H (0.45) TSHRTBXAS1ALDH1A1KCNA3NPC1
SCHEMBL6002506 0.72 TBXAS1 (0.70) TBXAS1ALDH1A1MAPTLTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130226549-A1 STRUCTURE-BASED FRAGMENT HOPPING FOR LEAD OPTIMIZATION AND IMPROVEMENT IN SYNTHETIC ACCESSIBILITY TSENG, YUFENG J. (TW) 2013-08-29 US disclosed