Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313787 | 0.90 | BCL2 (0.56) | BCL2ALDH1A1ADRB2MAPTMAPK1 | |
| SCHEMBL15313796 | 0.85 | BCL2 (0.54) | BCL2ALDH1A1ADRB2MAPTMAPK1 | |
| SCHEMBL15313820 | 0.81 | BCL2 (1.00) | BCL2ALDH1A1MAPTMAPK1BCL2L1 | |
| SCHEMBL15313790 | 0.80 | BCL2 (0.58) | BCL2ALDH1A1ADRB2MAPTSMN1; SMN2 | |
| SCHEMBL15313813 | 0.80 | TERT (0.58) | BCL2ALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL15313849 | 0.79 | BCL2 (0.67) | BCL2ALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL15313783 | 0.79 | BCL2 (0.59) | BCL2ALDH1A1MAPTSMN1; SMN2CRHBP | |
| SCHEMBL15313792 | 0.78 | BCL2 (0.58) | BCL2ALDH1A1ADRB2MAPK1SMN1; SMN2 | |
| SCHEMBL15313788 | 0.76 | BCL2 (0.62) | BCL2ALDH1A1ADRB2MAPK1SMN1; SMN2 | |
| SCHEMBL14372408 | 0.76 | ALDH1A1 (0.67) | ALDH1A1ADRB2MAPTSMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |