Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TERT | O14746 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | SELL | P14151 | 1/20 | 0.44 |
| ▸ | SELP | P16109 | 1/20 | 0.44 |
| ▸ | SELE | P16581 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313786 | 0.85 | BCL2 (0.67) | BCL2MAPTMAPK1CA12CA1 | |
| SCHEMBL15313813 | 0.83 | TERT (0.58) | BCL2MAPTMAPK1CA12CA1 | |
| SCHEMBL15313800 | 0.79 | BCL2L1 (0.60) | BCL2MAPTALDH1A1CRHBPCRHR2 | |
| SCHEMBL15313787 | 0.77 | BCL2 (0.56) | BCL2MAPTMAPK1CA1CA2 | |
| SCHEMBL14372408 | 0.74 | ALDH1A1 (0.67) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL15313820 | 0.70 | BCL2 (1.00) | BCL2MAPTMAPK1ALDH1A1KMT2A | |
| SCHEMBL15313849 | 0.70 | BCL2 (0.67) | BCL2MAPTMAPK1CA12CA1 | |
| SCHEMBL12190093 | 0.69 | PRMT1 (0.56) | MAPTMAPK1CA12CA1CA2 | |
| SCHEMBL11642995 | 0.69 | LMNA (0.56) | BCL2MAPTMAPK1ALDH1A1CRHBP | |
| SCHEMBL8663942 | 0.68 | MEN1 (0.61) | MAPTCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |