Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313788 | 0.81 | BCL2 (0.62) | BCL2MAPK1ALDH1A1ADRB2KDM4E | |
| SCHEMBL15313790 | 0.81 | BCL2 (0.58) | BCL2RAB9AALDH1A1ADRB2KDM4E | |
| SCHEMBL15313786 | 0.78 | BCL2 (0.67) | BCL2MAPK1ALDH1A1ADRB2KDM4E | |
| SCHEMBL15313778 | 0.77 | BCL2 (0.56) | BCL2ALDH1A1ADRB2KDM4ELMNA | |
| SCHEMBL15314355 | 0.77 | BCL2 (0.56) | BCL2PTGS2NPC1RAB9AALDH1A1 | |
| SCHEMBL27502192 | 0.76 | ALDH1A1 (0.67) | ALDH1A1ADRB2KDM4ELMNASMN1; SMN2 | |
| SCHEMBL15313795 | 0.76 | BCL2 (0.57) | BCL2MAPK1NPC1RAB9AALDH1A1 | |
| SCHEMBL15313783 | 0.76 | BCL2 (0.59) | BCL2ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL15313847 | 0.74 | BCL2 (1.00) | BCL2RAB9AALDH1A1ADRB2KDM4E | |
| SCHEMBL8768715 | 0.74 | PTGS1 (0.68) | PTGS1TBXAS1MAPK1PTGS2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |