Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15314355 | 0.89 | BCL2 (0.56) | BCL2KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL15313788 | 0.79 | BCL2 (0.62) | BCL2KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL15313792 | 0.77 | BCL2 (0.58) | BCL2KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL15313795 | 0.76 | BCL2 (0.57) | BCL2KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL15313790 | 0.76 | BCL2 (0.58) | BCL2KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL15928756 | 0.75 | ALDH1A1 (0.72) | KDM4EALDH1A1HCAR2L3MBTL1SMO | |
| SCHEMBL15313786 | 0.74 | BCL2 (0.67) | BCL2KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL15313824 | 0.73 | BCL2 (0.68) | BCL2KMT2A | |
| SCHEMBL15313847 | 0.72 | BCL2 (1.00) | BCL2KDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL22911554 | 0.71 | SMO (0.51) | LMNASMN1; SMN2ALDH1A1SMOMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |