Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.51 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313820 | 0.87 | BCL2 (1.00) | BCL2ALDH1A1BCL2L1HPGDKDM4E | |
| SCHEMBL28707306 | 0.81 | PTPN1 (0.73) | BCL2PTPN1PTPN2PTPN6BCL2L1 | |
| SCHEMBL15313899 | 0.81 | BCL2 (0.67) | BCL2ALDH1A1PTPN1PTPN2PTPN6 | |
| SCHEMBL15313824 | 0.81 | BCL2 (0.68) | BCL2BCL2L1KMT2AMAPT | |
| SCHEMBL15313814 | 0.80 | BCL2 (0.68) | BCL2ALDH1A1ADRB2HSPD1HSPE1 | |
| SCHEMBL15313853 | 0.80 | BCL2 (0.77) | BCL2BCL2L1KDM4ETP53RAB9A | |
| SCHEMBL15313905 | 0.80 | BCL2 (0.70) | BCL2ALDH1A1BCL2L1MEN1LMNA | |
| SCHEMBL8971238 | 0.80 | ALDH1A1 (0.73) | BCL2ALDH1A1ADRB2HPGDKDM4E | |
| SCHEMBL15313895 | 0.79 | BCL2L1 (0.84) | BCL2ALDH1A1BCL2L1LMNA | |
| SCHEMBL2169634 | 0.79 | MEN1 (0.68) | BCL2ALDH1A1ADRB2HSPD1HSPE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |