Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.58 |
| ▸ | FADS1 | O60427 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 2/20 | 0.43 |
| ▸ | KLK1 | P06870 | 2/20 | 0.43 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313792 | 0.81 | BCL2 (0.58) | BCL2ALDH1A1ADRB2LMNAKDM4E | |
| SCHEMBL15313786 | 0.80 | BCL2 (0.67) | BCL2ALDH1A1ADRB2LMNAKDM4E | |
| SCHEMBL15313836 | 0.78 | BCL2 (0.64) | BCL2LMNATP53MAPT | |
| SCHEMBL15313778 | 0.76 | BCL2 (0.56) | BCL2ALDH1A1ADRB2LMNAKDM4E | |
| SCHEMBL15314355 | 0.76 | BCL2 (0.56) | BCL2ALDH1A1ADRB2LMNAKDM4E | |
| SCHEMBL15313788 | 0.76 | BCL2 (0.62) | BCL2ALDH1A1ADRB2LMNAKDM4E | |
| SCHEMBL15313795 | 0.75 | BCL2 (0.57) | BCL2ALDH1A1ADRB2LMNAKDM4E | |
| SCHEMBL15313847 | 0.74 | BCL2 (1.00) | BCL2ALDH1A1ADRB2LMNAKDM4E | |
| SCHEMBL15313787 | 0.74 | BCL2 (0.56) | BCL2ALDH1A1ADRB2LMNASMN1; SMN2 | |
| SCHEMBL8283426 | 0.72 | KCNK9 (0.69) | FADS1LMNASMN1; SMN2HTTNLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |