Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313778 | 0.76 | BCL2 (0.56) | BCL2ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL15313792 | 0.76 | BCL2 (0.58) | BCL2ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL15313788 | 0.76 | BCL2 (0.62) | BCL2ALDH1A1KDM4ELMNAMAPK1 | |
| SCHEMBL15313790 | 0.75 | BCL2 (0.58) | BCL2ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL15314355 | 0.74 | BCL2 (0.56) | BCL2ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL15313847 | 0.73 | BCL2 (1.00) | BCL2ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL15313786 | 0.73 | BCL2 (0.67) | BCL2ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL15313783 | 0.73 | BCL2 (0.59) | BCL2ALDH1A1KDM4ELMNAPOLB | |
| SCHEMBL15313791 | 0.71 | LMNA (0.57) | ALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL3690385 | 0.70 | HPGD (0.77) | ALDH1A1HPGDKDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |