Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | BCL2 | P10415 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313796 | 0.83 | BCL2 (0.54) | TERTMAPTSMN1; SMN2ALDH1A1BCL2 | |
| SCHEMBL9051568 | 0.81 | MEN1 (0.65) | TERTALDH1A1BCL2LMNAHPGD | |
| SCHEMBL15313786 | 0.80 | BCL2 (0.67) | TERTMAPTSMN1; SMN2ALDH1A1BCL2 | |
| SCHEMBL15313839 | 0.77 | CA12 (0.53) | TERTMAPTSMN1; SMN2ALDH1A1BCL2 | |
| SCHEMBL15313840 | 0.76 | FADS1 (0.49) | TERTCA2MEN1KMT2A | |
| SCHEMBL15313832 | 0.76 | BCL2L1 (0.63) | ALDH1A1BCL2P2RX1LMNACA12 | |
| SCHEMBL15313849 | 0.75 | BCL2 (0.67) | MAPTSMN1; SMN2ALDH1A1BCL2CRHBP | |
| SCHEMBL845143 | 0.75 | TERT (0.80) | TERTSMN1; SMN2ALDH1A1P2RX1LMNA | |
| SCHEMBL29405216 | 0.75 | TERT (1.00) | TERTSMN1; SMN2P2RX1LMNAHPGD | |
| SCHEMBL17005794 | 0.75 | TERT (1.00) | TERTSMN1; SMN2P2RX1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |