Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | TERT | O14746 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | KLK1 | P06870 | 2/20 | 0.44 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313834 | 0.92 | ALOX12 (0.54) | FADS1CA2ALOX12PLGKLK1 | |
| SCHEMBL15313839 | 0.83 | CA12 (0.53) | TERTCA2MEN1KMT2A | |
| SCHEMBL15313830 | 0.77 | GPR27 (0.61) | MEN1KMT2AGPR27 | |
| SCHEMBL15313813 | 0.76 | TERT (0.58) | TERTCA2MEN1KMT2A | |
| SCHEMBL15313836 | 0.75 | BCL2 (0.64) | ALOX12KMT2AGPR27 | |
| SCHEMBL15313841 | 0.73 | BCL2 (0.64) | FADS1CA2ALOX12KMT2AGPR27 | |
| SCHEMBL10169497 | 0.73 | HTR6 (0.59) | PKMCA2ALOX12MEN1KMT2A | |
| SCHEMBL23988608 | 0.72 | EPHB4 (0.47) | PKMCA2IDH2MEN1KMT2A | |
| SCHEMBL17774888 | 0.71 | FADS1 (0.66) | FADS1TERTCA2AKR1C3PLG | |
| SCHEMBL23200288 | 0.71 | KCNA5 (0.64) | FADS1MEN1KMT2AGPR27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |