Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 4/20 | 0.64 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
| ▸ | GPR27 | Q9NS67 | 11/20 | 0.46 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313841 | 0.89 | BCL2 (0.64) | BCL2BCL2L1ALOX12MCL1SIRT5 | |
| SCHEMBL15313824 | 0.88 | BCL2 (0.68) | BCL2BCL2L1GPR27AVPR2KMT2A | |
| SCHEMBL15313838 | 0.84 | BCL2 (0.66) | BCL2BCL2L1MCL1SIRT5GPR27 | |
| SCHEMBL15313905 | 0.84 | BCL2 (0.70) | BCL2BCL2L1MCL1SIRT5GPR27 | |
| SCHEMBL15313834 | 0.83 | ALOX12 (0.54) | ALOX12GPR27AVPR2KMT2A | |
| SCHEMBL15313827 | 0.80 | BCL2 (0.64) | BCL2BCL2L1MCL1SIRT5GPR27 | |
| SCHEMBL15313820 | 0.79 | BCL2 (1.00) | BCL2BCL2L1MCL1SIRT5KMT2A | |
| SCHEMBL15313844 | 0.79 | BCL2 (0.55) | BCL2BCL2L1ALOX12MCL1SIRT5 | |
| SCHEMBL15313847 | 0.79 | BCL2 (1.00) | BCL2BCL2L1ALOX12KMT2ALMNA | |
| SCHEMBL15313790 | 0.78 | BCL2 (0.58) | BCL2LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |