Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.77 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.54 |
| ▸ | NAMPT | P43490 | 3/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.46 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.46 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313820 | 0.87 | BCL2 (1.00) | BCL2BCL2L1NAMPTMCL1SIRT5 | |
| SCHEMBL15313857 | 0.86 | BCL2 (0.56) | BCL2BCL2L1NAMPTMCL1SIRT5 | |
| SCHEMBL15313858 | 0.86 | BCL2 (0.56) | BCL2BCL2L1NAMPTMCL1SIRT5 | |
| SCHEMBL15313847 | 0.80 | BCL2 (1.00) | BCL2BCL2L1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL15313895 | 0.79 | BCL2L1 (0.84) | BCL2BCL2L1NAMPTMCL1SIRT5 | |
| SCHEMBL15313905 | 0.76 | BCL2 (0.70) | BCL2BCL2L1MCL1SIRT5PRMT1 | |
| SCHEMBL15313824 | 0.74 | BCL2 (0.68) | BCL2BCL2L1NAMPT | |
| SCHEMBL15313838 | 0.73 | BCL2 (0.66) | BCL2BCL2L1MCL1SIRT5SMN1; SMN2 | |
| SCHEMBL15313807 | 0.73 | BCL2L1 (0.79) | BCL2BCL2L1NAMPTMCL1SIRT5 | |
| SCHEMBL15313836 | 0.72 | BCL2 (0.64) | BCL2BCL2L1NAMPTMCL1SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |