Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 2/20 | 0.68 |
| ▸ | GPR27 | Q9NS67 | 10/20 | 0.56 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313836 | 0.88 | BCL2 (0.64) | BCL2GPR27AVPR2NAMPTMAPT | |
| SCHEMBL15313827 | 0.86 | BCL2 (0.64) | BCL2GPR27AVPR2NAMPTMAPT | |
| SCHEMBL15313830 | 0.81 | GPR27 (0.61) | GPR27AVPR2NAMPTMAPTKMT2A | |
| SCHEMBL15313820 | 0.81 | BCL2 (1.00) | BCL2NAMPTMAPTBCL2L1KMT2A | |
| SCHEMBL15313838 | 0.81 | BCL2 (0.66) | BCL2GPR27AVPR2BCL2L1KMT2A | |
| SCHEMBL15313847 | 0.81 | BCL2 (1.00) | BCL2MAPTBCL2L1KMT2A | |
| SCHEMBL15313905 | 0.80 | BCL2 (0.70) | BCL2GPR27AVPR2MAPTBCL2L1 | |
| SCHEMBL15313841 | 0.77 | BCL2 (0.64) | BCL2GPR27AVPR2MAPTBCL2L1 | |
| SCHEMBL15313895 | 0.76 | BCL2L1 (0.84) | BCL2NAMPTBCL2L1 | |
| SCHEMBL15313853 | 0.74 | BCL2 (0.77) | BCL2NAMPTBCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |