Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | GPR27 | Q9NS67 | 10/20 | 0.52 |
| ▸ | AVPR2 | P30518 | 5/20 | 0.50 |
| ▸ | PLG | P00747 | 2/20 | 0.49 |
| ▸ | KLK1 | P06870 | 2/20 | 0.49 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | FADS1 | O60427 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313840 | 0.92 | FADS1 (0.49) | ALOX12CA2GPR27PLGKLK1 | |
| SCHEMBL15313830 | 0.86 | GPR27 (0.61) | GPR27AVPR2KMT2ASNCA | |
| SCHEMBL15313836 | 0.83 | BCL2 (0.64) | ALOX12GPR27AVPR2KMT2A | |
| SCHEMBL15313841 | 0.81 | BCL2 (0.64) | ALOX12CA2GPR27AVPR2KMT2A | |
| SCHEMBL15313835 | 0.80 | CA12 (0.51) | CA2GPR27AVPR2KMT2A | |
| SCHEMBL15313831 | 0.77 | GPR27 (0.61) | GPR27AVPR2KMT2A | |
| SCHEMBL15313910 | 0.77 | MEN1 (0.50) | ALOX12CA2GPR27AVPR2KMT2A | |
| SCHEMBL15313839 | 0.75 | CA12 (0.53) | CA2KMT2A | |
| SCHEMBL26546924 | 0.74 | ALOX12 (0.67) | ALOX12CA2 | |
| SCHEMBL15474323 | 0.74 | CA2 (0.61) | ALOX12CA2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |