Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 5/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313853 | 0.86 | BCL2 (0.77) | BCL2BCL2L1POLBMCL1SIRT5 | |
| SCHEMBL15313820 | 0.73 | BCL2 (1.00) | BCL2BCL2L1LMNAMCL1SIRT5 | |
| SCHEMBL15313857 | 0.73 | BCL2 (0.56) | BCL2BCL2L1LMNAPOLBMCL1 | |
| SCHEMBL15313785 | 0.72 | BCL2 (0.67) | BCL2BCL2L1LMNAPOLBMCL1 | |
| SCHEMBL15313795 | 0.70 | BCL2 (0.57) | BCL2LMNAPOLBALDH1A1HTT | |
| SCHEMBL15313819 | 0.70 | BCL2 (0.79) | BCL2BCL2L1LMNAPOLBCCR8 | |
| SCHEMBL15313847 | 0.69 | BCL2 (1.00) | BCL2BCL2L1LMNAALDH1A1HTT | |
| SCHEMBL15313895 | 0.68 | BCL2L1 (0.84) | BCL2BCL2L1LMNAMCL1SIRT5 | |
| SCHEMBL15313824 | 0.67 | BCL2 (0.68) | BCL2BCL2L1NAMPT | |
| SCHEMBL15313911 | 0.67 | BCL2 (0.53) | BCL2BCL2L1LMNAPOLBMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |