Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ARG1 | P05089 | 1/20 | 0.32 |
| ▸ | ARG2 | P78540 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12009951 | 0.93 | ARG1 (0.31) | SMN1; SMN2LTA4HARG1ARG2 | |
| SCHEMBL421373 | 0.84 | ALDH1A1 (0.40) | SMN1; SMN2LTA4HLMNAMAPTL3MBTL1 | |
| SCHEMBL19102455 | 0.82 | SMN1; SMN2 (0.36) | SMN1; SMN2LMNAHRH3MAPTCYP2D6 | |
| SCHEMBL13730325 | 0.82 | SMN1; SMN2 (0.33) | SMN1; SMN2LTA4HARG1ARG2HTT | |
| SCHEMBL18717218 | 0.79 | HRH3 (0.36) | SMN1; SMN2HRH3 | |
| SCHEMBL14472771 | 0.78 | — | — | |
| SCHEMBL15138014 | 0.77 | SMN1; SMN2 (0.35) | SMN1; SMN2HRH3 | |
| SCHEMBL13730333 | 0.76 | SMN1; SMN2 (0.30) | SMN1; SMN2 | |
| SCHEMBL14472607 | 0.75 | — | — | |
| SCHEMBL14286498 | 0.75 | APEX1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557231-B2 | Biodegradable poly(beta-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-10-15 | — | — | US | disclosed |