Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | DGKA | P23743 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421380 | 0.86 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL15314276 | 0.84 | SMN1; SMN2 (0.35) | L3MBTL1SMN1; SMN2LTA4HLMNAMAPT | |
| SCHEMBL13988123 | 0.84 | SMN1; SMN2 (0.43) | ALDH1A1L3MBTL1SMN1; SMN2LMNAMAPT | |
| SCHEMBL420320 | 0.82 | CHRM1 (0.46) | ALDH1A1L3MBTL1SMN1; SMN2DGKAMAPT | |
| SCHEMBL13601455 | 0.80 | POLB (0.51) | ALDH1A1L3MBTL1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL420355 | 0.80 | HRH1 (0.47) | ALDH1A1L3MBTL1SMN1; SMN2MAPTTSHR | |
| SCHEMBL419258 | 0.79 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL674334 | 0.79 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL13730325 | 0.79 | SMN1; SMN2 (0.33) | ALDH1A1SMN1; SMN2LTA4HTSHRCHRM4 | |
| SCHEMBL12009951 | 0.78 | ARG1 (0.31) | SMN1; SMN2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9700627-B2 | Biodegradable poly (beta-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2017-07-11 | — | — | US | disclosed |
| US-20160022821-A1 | BIODEGRADABLE POLY (BETA-AMINO ESTERS) AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-01-28 | — | — | US | disclosed |
| US-9101666-B2 | Biodegradable poly(beta-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-08-11 | — | — | US | disclosed |
| US-8557231-B2 | Biodegradable poly(beta-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-10-15 | — | — | US | disclosed |
| US-8287849-B2 | Biodegradable poly(beta-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-10-16 | — | — | US | disclosed |
| US-RE43612-E1 | Biodegradable poly(β-amino esters) and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-08-28 | — | — | US | disclosed |
| US-20120065358-A1 | BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-03-15 | — | — | US | disclosed |
| US-7943179-B2 | Drug delivery particle; useful in genetic vaccination; eg poly(beta-amino esters) | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2011-05-17 | — | — | US | disclosed |
| US-20110059172-A1 | THERAPEUTIC COMPOSITIONS | TZIANABOS ARTHUR | 2011-03-10 | — | — | US | disclosed |
| US-20100036084-A1 | BIODEGRADABLE POLY(BETA-AMINO ESTERS) AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-02-11 | — | — | US | disclosed |
| US-7427394-B2 | Delivering labile agents; buffering effect; transfecting nucleic acids; nontoxic | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2008-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160022821-A1 | BIODEGRADABLE POLY (BETA-AMINO ESTERS) AND USES THEREOF | PARN, PARG, NPEPPS | ALDH1A1 2245/4885L3MBTL1 480/4885SMN1; SMN2 490/4885 |
| US-20110059172-A1 | THERAPEUTIC COMPOSITIONS | PHOSPHO1, ACP1, TUBB3 | ALDH1A1 1769/4885L3MBTL1 841/4885SMN1; SMN2 409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.