Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28758384 | 0.80 | SLC6A2 (0.40) | SLC6A4HTT | |
| SCHEMBL16534913 | 0.74 | HSD17B10 (0.41) | MTNR1AMTNR1BKDM4EALDH1A1TYMS | |
| SCHEMBL16535135 | 0.71 | KDM4E (0.39) | MTNR1AMTNR1BKDM4EALDH1A1TYMS | |
| SCHEMBL5573010 | 0.70 | MTNR1A (0.60) | MTNR1AMTNR1BKDM4ECYP3A4TSHR | |
| SCHEMBL18536371 | 0.69 | ADRA2A (0.38) | TSHRSLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL16534999 | 0.68 | MTNR1A (0.43) | MTNR1AMTNR1BKDM4EALDH1A1TYMS | |
| SCHEMBL9904585 | 0.68 | HTR1A (0.40) | ADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL16534705 | 0.68 | ALDH1A1 (0.33) | MTNR1AMTNR1BKDM4EALDH1A1HTT | |
| SCHEMBL13197463 | 0.67 | ALDH1A1 (0.51) | ALDH1A1CYP1A2CYP2C19TSHRADRA2A | |
| SCHEMBL16535010 | 0.67 | TYMS (0.44) | KDM4EALDH1A1TYMSCYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834233-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | Orion Corporation (FI) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013150173-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | ORION CORPORATION (FI) | 2013-10-10 | — | — | WO | disclosed |