Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11559279 | 0.88 | LMNA (0.40) | PRCPDPP7ALDH1A1LMNAHTR2C | |
| SCHEMBL8518994 | 0.83 | LMNA (0.42) | PRCPCYP3A4CYP2D6ALDH1A1LMNA | |
| SCHEMBL11560266 | 0.82 | TSHR (0.38) | PRCPDPP7LMNAELANENOS2 | |
| SCHEMBL8518486 | 0.82 | LMNA (0.45) | PRCPCYP3A4CYP2D6ALDH1A1LMNA | |
| SCHEMBL542283 | 0.81 | NOS2 (0.39) | PRCPDPP7HTR2CELANENOS2 | |
| Succinic Acid SCHEMBL15323281 | 0.80 | PRCP (0.42) | PRCPKDM4EDPP7ALDH1A1NOS2 | |
| SCHEMBL9362980 | 0.79 | PRCP (0.44) | PRCPKDM4EDPP7TLR2ELANE | |
| SCHEMBL30265157 | 0.79 | PRCP (0.44) | PRCPKDM4EDPP7TLR2ELANE | |
| SCHEMBL15323736 | 0.79 | CYP3A4 (0.37) | PRCPKDM4EDPP7CYP1A2CYP3A4 | |
| SCHEMBL599792 | 0.78 | ALDH1A1 (0.45) | PRCPDPP7ALDH1A1TLR2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |