Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL1532415 | 0.91 | LMNA (0.55) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Propylene Glycol SCHEMBL16666994 | 0.88 | LMNA (0.50) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Propylene Glycol SCHEMBL118981 | 0.87 | LMNA (0.67) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Propylene Glycol SCHEMBL18338987 | 0.82 | TDP1 (0.62) | LMNATDP1ALDH1A1TSHR | |
| Propylene Glycol SCHEMBL872897 | 0.81 | LMNA (0.52) | LMNATDP1TSHR | |
| Propylene Glycol SCHEMBL10380801 | 0.80 | LMNA (0.57) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Acetone SCHEMBL590699 | 0.79 | LMNA (0.71) | LMNATDP1ALDH1A1HSD17B10TSHR | |
| Propylene Glycol SCHEMBL9621813 | 0.79 | LMNA (0.50) | LMNATDP1ALDH1A1TSHR | |
| Propylene Glycol SCHEMBL873404 | 0.78 | GAA (0.45) | LMNATDP1ALDH1A1HSD17B10 | |
| Lactic Acid SCHEMBL6153357 | 0.78 | LMNA (0.60) | LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592621-B2 | Precursor compounds of sweet taste receptor antagonists for the prevention or treatment of disease | SYMRISE AG (DE) | 2013-11-26 | — | — | US | claimed |
| US-20110045069-A1 | PRECURSOR COMPOUNDS OF SWEET TASTE RECEPTOR ANTAGONISTS FOR THE PREVENTION OR TREATMENT OF DISEASE | SYMRISE GMBH CO. KG (DE) | 2011-02-24 | — | — | US | claimed |
| US-20240410055-A1 | METHOD AND FORMULATION FOR PREPARING OPTICAL METAL OXIDE LAYERS | MERCK PATENT GMBH (DE) | 2024-12-12 | — | — | US | disclosed |
| US-12121637-B2 | Method of atomizing a fluid composition | THE PROCTER & GAMBLE COMPANY (US) | 2024-10-22 | — | — | US | disclosed |
| US-12036341-B2 | Freshening compositions and methods of atomizing freshening compositions with a thermally-actuated microfluidic cartridge | THE PROCTER & GAMBLE COMPANY (US) | 2024-07-16 | — | — | US | disclosed |
| CN-114007660-B | Refreshing composition and method for atomizing refreshing composition by using heat-activated microfluidic cartridge | 宝洁公司 | 2024-07-05 | — | — | CN | disclosed |
| EP-3999344-B1 | METHOD OF ATOMIZING A FLUID COMPOSITION | PROCTER & GAMBLE (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118076767-A | Method and formulation for producing an optical metal oxide layer | 默克专利有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-114096283-B | Method of atomizing a fluid composition | 宝洁公司 | 2024-04-16 | — | — | CN | disclosed |
| WO-2023057401-A1 | METHOD AND FORMULATION FOR PREPARING OPTICAL METAL OXIDE LAYERS | MERCK PATENT GMBH (DE) | 2023-04-13 | — | — | WO | disclosed |
| EP-3999344-A1 | METHOD OF ATOMIZING A FLUID COMPOSITION | The Procter & Gamble Company (US) | 2022-05-25 | — | — | EP | disclosed |
| CN-114007660-A | Freshening composition and method for atomizing freshening composition with heat-activated microfluidic cartridge | 宝洁公司 | 2022-02-01 | — | — | CN | disclosed |
| US-20210015957-A1 | METHOD OF ATOMIZING A FLUID COMPOSITION | THE PROCTER & GAMBLE COMPANY | 2021-01-21 | — | — | US | disclosed |
| WO-2021011959-A1 | METHOD OF ATOMIZING A FLUID COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2021-01-21 | — | — | WO | disclosed |
| WO-2021011961-A1 | METHOD OF ATOMIZING A FLUID COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2021-01-21 | — | — | WO | disclosed |
| WO-2021011958-A1 | FRESHENING COMPOSITIONS AND METHODS OF ATOMIZING FRESHENING COMPOSITIONS WITH A THERMALLY-ACTUATED MICROFLUIDIC CARTRIDGE | THE PROCTER & GAMBLE COMPANY (US) | 2021-01-21 | — | — | WO | disclosed |
| US-20210016307-A1 | FRESHENING COMPOSITIONS AND METHODS OF ATOMIZING FRESHENING COMPOSITIONS WITH A THERMALLY-ACTUATED MICROFLUIDIC CARTRIDGE | THE PROCTER & GAMBLE COMPANY | 2021-01-21 | — | — | US | disclosed |
| US-20210015958-A1 | METHOD OF ATOMIZING A FLUID COMPOSITION | THE PROCTER & GAMBLE COMPANY | 2021-01-21 | — | — | US | disclosed |
| US-8592621-B2 | Precursor compounds of sweet taste receptor antagonists for the prevention or treatment of disease | SYMRISE AG (DE) | 2013-11-26 | — | — | US | disclosed |
| US-20110045069-A1 | PRECURSOR COMPOUNDS OF SWEET TASTE RECEPTOR ANTAGONISTS FOR THE PREVENTION OR TREATMENT OF DISEASE | SYMRISE GMBH CO. KG (DE) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110045069-A1 | PRECURSOR COMPOUNDS OF SWEET TASTE RECEPTOR ANTAGONISTS FOR THE PREVENTION OR TREATMENT OF DISEASE | TAS1R2, TAS2R5, TAS2R1 | LMNA 3996/4885TDP1 4364/4885ALDH1A1 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.