SCHEMBL1533543

SCHEMBL1533543

O=c1cc(Cl)sn1-c1ccc([N+](=O)[O-])cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KAT2B Q92831 7/20 1.00
MIF P14174 1/20 0.51
PHOSPHO1 Q8TCT1 3/20 0.43
G6PD P11413 1/20 0.43
TLR9 Q9NR96 1/20 0.43
MAPT P10636 5/20 0.41
ALDH1A1 P00352 2/20 0.41
SCN2A Q99250 1/20 0.41
GSK3A P49840 1/20 0.41
GSK3B P49841 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
LMNA P02545 2/20 0.40
HTT P42858 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
RAB9A P51151 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7623894 0.79 KAT2B (0.67) KAT2BMIFG6PDMAPTALDH1A1
SCHEMBL11193393 0.75 KAT2B (0.60) KAT2BPHOSPHO1G6PDTLR9MAPT
SCHEMBL2108805 0.73 KAT2B (0.73) KAT2BPHOSPHO1MAPTMEN1KMT2A
SCHEMBL81082 0.71 KAT2B (0.59) KAT2BMAPTALDH1A1SCN2APKM
SCHEMBL1896800 0.66 PHOSPHO1 (0.70) KAT2BMIFPHOSPHO1G6PDTLR9
SCHEMBL9187712 0.65 GSK3A (0.56) KAT2BMAPTALDH1A1SCN2AGSK3A
SCHEMBL27909482 0.65 ALDH1A1 (0.72) ALDH1A1HSD17B10MEN1KMT2ALMNA
SCHEMBL22567 0.65 ALDH1A1 (0.72) ALDH1A1HSD17B10MEN1KMT2ALMNA
SCHEMBL23878375 0.65 MAPT (0.51) KAT2BMAPTALDH1A1SCN2AHSD17B10
SCHEMBL9320105 0.65 KAT2B (0.47) KAT2BMAPTALDH1A1SCN2AGSK3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12605407-B2 Methods to induce terminal differentiation in stem cells by interfering with DNA replication, methods of inducing pancreatic differentiation, and differentiated cells obtained thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2026-04-21 US claimed
US-20250075176-A1 COMPOSITIONS COMPRISING HISTONE ACETYLTRANSFERASE INHIBITORS OR REVERSE TRANSCRIPTASE INHIBITORS AND USE THEREOF FOREVE LABS LTD. (IL) 2025-03-06 US claimed
CN-119343442-A Compositions comprising histone acetyltransferase inhibitors or reverse transcriptase inhibitors and uses thereof 永恒实验室公司 2025-01-21 CN claimed
EP-4490269-A1 COMPOSITIONS COMPRISING HISTONE ACETYLTRANSFERASE INHIBITORS OR REVERSE TRANSCRIPTASE INHIBITORS AND USE THEREOF Foreve Labs Ltd. (IL) 2025-01-15 EP claimed
WO-2023170667-A1 COMPOSITIONS COMPRISING HISTONE ACETYLTRANSFERASE INHIBITORS OR REVERSE TRANSCRIPTASE INHIBITORS AND USE THEREOF FOREVE LABS LTD. (IL) 2023-09-14 WO claimed
EP-3813852-A1 METHODS TO INDUCE TERMINAL DIFFERENTIATION IN STEM CELLS BY INTERFERING WITH DNA REPLICATION, METHODS OF INDUCING PANCREATIC DIFFERENTIATION, AND DIFFERENTIATED CELLS OBTAINED THEREOF The Trustees of Columbia University in the City of New York (US) 2021-05-05 EP claimed
US-20210052665-A1 METHODS TO INDUCE TERMINAL DIFFERENTIATION IN STEM CELLS BY INTERFERING WITH DNA REPLICATION, METHODS OF INDUCING PANCREATIC DIFFERENTIATION, AND DIFFERENTIATED CELLS OBTAINED THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2021-02-25 US claimed
US-20090027774-A1 COMPOSITION FOR ANISOTROPIC DYESTUFF FILM, ANISOTROPIC DYESTUFF FILM AND POLARIZING ELEMENT MITSUBISHI CHEMICAL CORPORATION (JP) 2009-01-29 US claimed
EP-1860469-A1 COMPOSITION FOR ANISOTROPIC DYESTUFF FILM, ANISOTROPIC DYESTUFF FILM AND POLARIZING ELEMENT MITSUBISHI CHEMICAL CORPORATION (JP) 2007-11-28 EP claimed
EP-4748838-A1 BROAD SPECTRUM ANTI-CANCER COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-05-27 EP disclosed
US-12630527-B2 Broad spectrum anti-cancer compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-05-19 US disclosed
US-12605407-B2 Methods to induce terminal differentiation in stem cells by interfering with DNA replication, methods of inducing pancreatic differentiation, and differentiated cells obtained thereof THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2026-04-21 US disclosed
EP-4045498-B1 BROAD SPECTRUM ANTI-CANCER COMPOUNDS UNIV CALIFORNIA (US) 2025-12-03 EP disclosed
EP-4652455-A2 METHODS FOR ANALYSIS OF CELL-FREE NUCLEIC ACIDS IN URINE Grail, Inc. (US) 2025-11-26 EP disclosed
US-20110177315-A1 DICHROIC DYE COMPOSITION, LIGHT ABSORPTION ANISOTROPIC FILM, AND POLARIZING ELEMENT FUJIFILM CORPORATION (JP) 2011-07-21 US disclosed
WO-2011030883-A1 COLOR FILTER AND LIGHT-EMITTING DISPLAY ELEMENT FUJIFILM CORPORATION (JP) 2011-03-17 WO disclosed
US-20100134726-A1 POLARIZING ELEMENT AND METHOD OF PRODUCING THE SAME FUJIFILM CORPORATION (JP) 2010-06-03 US disclosed
US-20090274853-A1 DICHROIC DYE COMPOSITION FUJIFILM CORPORATION (JP) 2009-11-05 US disclosed
US-20090027774-A1 COMPOSITION FOR ANISOTROPIC DYESTUFF FILM, ANISOTROPIC DYESTUFF FILM AND POLARIZING ELEMENT MITSUBISHI CHEMICAL CORPORATION (JP) 2009-01-29 US disclosed
EP-1860469-A1 COMPOSITION FOR ANISOTROPIC DYESTUFF FILM, ANISOTROPIC DYESTUFF FILM AND POLARIZING ELEMENT MITSUBISHI CHEMICAL CORPORATION (JP) 2007-11-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630527-B2 Broad spectrum anti-cancer compounds YTHDF3, YTHDF1, YTHDF2 KAT2B 2423/4885MIF 1365/4885PHOSPHO1 2978/4885
US-20090274853-A1 DICHROIC DYE COMPOSITION C1S, CDY1; CDY1B, CRY1 KAT2B 1623/4885MIF 4449/4885PHOSPHO1 2066/4885
US-12605407-B2 Methods to induce terminal differentiation in stem cells by interfering with DNA replication, methods of inducing pancreatic differentiation, and differentiated cells obtained thereof CCND1, CCNB3, MKI67 KAT2B 2199/4885MIF 3927/4885PHOSPHO1 2645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.