Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ERN1 | O75460 | 5/20 | 0.48 |
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.41 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1039129 | 0.91 | ALDH1A1 (0.72) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL8076637 | 0.89 | ALDH1A1 (0.68) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL18232228 | 0.89 | ALDH1A1 (0.61) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL282147 | 0.87 | ALDH1A1 (0.54) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL24311483 | 0.87 | ALDH1A1 (0.72) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL10849623 | 0.86 | ALDH1A1 (0.86) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| Asaraldehyde SCHEMBL333451 | 0.84 | ALDH1A1 (1.00) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| Asaraldehyde SCHEMBL29456596 | 0.84 | ALDH1A1 (1.00) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL3136850 | 0.84 | ALDH1A1 (0.90) | ALDH1A1KDM4ETSHRTDP1HPGD | |
| SCHEMBL697093 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KDM4ETSHRTDP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112538079-B | Coumarin derivative and synthesis method and application thereof | 中国药科大学 | 2022-12-27 | — | — | CN | disclosed |
| CN-112538079-A | Coumarin derivative and synthesis method and application thereof | 中国药科大学 | 2021-03-23 | — | — | CN | disclosed |
| US-10442779-B2 | Compositions and methods for treating Friedreich's ataxia | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2019-10-15 | — | — | US | disclosed |
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. | 2019-04-18 | — | — | US | disclosed |
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. | 2019-04-18 | — | — | US | disclosed |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | Prosetta Antiviral, Inc. (US) | 2019-02-05 | — | — | US | disclosed |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | Prosetta Antiviral, Inc. (US) | 2019-02-05 | — | — | US | disclosed |
| US-9957214-B2 | Multifunctional radical quenchers | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170368051-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-12-28 | — | — | US | disclosed |
| US-20170368051-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-12-28 | — | — | US | disclosed |
| WO-2011033265-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2011-03-24 | — | — | WO | disclosed |
| CN-101796043-A | Benzofuran-and benzo [ b ] thiophene-2-carboxylic acid amide derivatives and their use as histamine 3 receptor modulators | HOFFMANN LA ROCHE | 2010-08-04 | — | — | CN | disclosed |
| EP-2183237-A1 | BENZOFURAN- AND BENZO[B]THIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AND USE THEREOF AS HISTAMINE 3 RECEPTOR MODULATORS | F. Hoffmann-Roche AG (CH) | 2010-05-12 | — | — | EP | disclosed |
| US-7534788-B2 | Benzofuran and benzothiophene-2-carboxylic acid amide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-05-19 | — | — | US | disclosed |
| WO-2009013195-A1 | BENZOFURAN- AND BENZO[B]THIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AND USE THEREOF AS HISTAMINE 3 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | WO | disclosed |
| US-20090029976-A1 | BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2009-01-29 | — | — | US | disclosed |
| US-7429616-B2 | Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2007011629-A2 | SYNTHESIS AND COMPLETE STEREOCHEMICAL ASSIGNMENT OF PSYMBERIN/IRCINIASTATIN FOR ANTI-TUMOR USE | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2007-01-25 | — | — | WO | disclosed |
| US-20070015821-A1 | Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM | 2007-01-18 | — | — | US | disclosed |
| US-4024274-A | Benzylamine derivatives and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | MAVS, EIF2AK2, POLRMT | ALDH1A1 3748/4885KDM4E 289/4885TSHR 4860/4885 |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | MAVS, EIF2AK2, POLRMT | ALDH1A1 3748/4885KDM4E 289/4885TSHR 4860/4885 |
| US-20090029976-A1 | BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES | HCAR2, HCAR1, HRH3 | ALDH1A1 180/4885KDM4E 793/4885TSHR 184/4885 |
| US-20070015821-A1 | Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds | HCCS, RPS24, RPS27 | ALDH1A1 3015/4885KDM4E 4248/4885TSHR 4205/4885 |
| US-10442779-B2 | Compositions and methods for treating Friedreich's ataxia | ATXN10, ATXN2, ATXN2L | ALDH1A1 2488/4885KDM4E 815/4885TSHR 4774/4885 |
| US-20170368051-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | MAVS, EIF2AK2, POLRMT | ALDH1A1 3748/4885KDM4E 289/4885TSHR 4860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.