Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.63 |
| ▸ | HTR6 | P50406 | 12/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17742865 | 0.91 | PDPK1 (0.77) | PDPK1HTR6CA12CA9CA1 | |
| SCHEMBL15397145 | 0.86 | PDPK1 (0.84) | PDPK1HTR6 | |
| SCHEMBL12501057 | 0.78 | PDPK1 (1.00) | PDPK1 | |
| SCHEMBL16698105 | 0.72 | PDPK1 (0.54) | PDPK1HTR6CA12CA9CA1 | |
| SCHEMBL3328845 | 0.71 | L3MBTL1 (0.54) | HTR6CA12CA9L3MBTL1 | |
| SCHEMBL22777950 | 0.69 | PDPK1 (0.49) | PDPK1HTR6CA12CA9CA1 | |
| SCHEMBL29714399 | 0.69 | PDPK1 (0.49) | PDPK1HTR6CA12CA9CA1 | |
| SCHEMBL19662767 | 0.68 | MET (0.55) | CREBBPAXLMET | |
| SCHEMBL16703358 | 0.68 | GRM4 (0.65) | HTR6L3MBTL1HTR7HTR1AMET | |
| SCHEMBL17785973 | 0.68 | MET (0.55) | CREBBPAXLMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160130269-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130269-A1 | 7-AZAINDOLE DERIVATIVES | PDK1, PDK2, PDK3 | PDPK1 12/4885HTR6 3525/4885CA12 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.