Sugi Predict

Sugi Predict / Compounds / SCHEMBL1541188

SCHEMBL1541188

SCHEMBL1541188

O=[N+]([O-])c1ccc2[nH]c(Cl)nc2c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.56
▸ MAPT P10636 7/20 0.50
▸ NPBWR1 P48145 5/20 0.50
▸ MEN1 O00255 4/20 0.50
▸ KMT2A Q03164 4/20 0.50
▸ NPC1 O15118 3/20 0.50
▸ HTT P42858 3/20 0.50
▸ RAB9A P51151 3/20 0.50
▸ LMNA P02545 3/20 0.50
▸ SMN1; SMN2 Q16637 2/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50
▸ HPGD P15428 1/20 0.50
▸ POLB P06746 2/20 0.49
▸ MAOB P27338 1/20 0.49
▸ NOS1 P29475 1/20 0.49
▸ GRIA1 P42261 1/20 0.49
▸ GRIA2 P42262 1/20 0.49
▸ GRIA3 P42263 1/20 0.49
▸ GRIA4 P48058 1/20 0.49
▸ MMP2 P08253 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1541190 0.87 ALDH1A1 (0.67) ALDH1A1MAPTNPBWR1MEN1KMT2A
SCHEMBL4328210 0.81 ALDH1A1 (0.58) ALDH1A1MAPTNPBWR1MEN1KMT2A
SCHEMBL18758065 0.81 ALDH1A1 (0.58) ALDH1A1MAPTNPBWR1MEN1KMT2A
SCHEMBL2711226 0.81 ALDH1A1 (0.58) ALDH1A1MAPTNPBWR1MEN1KMT2A
SCHEMBL27567547 0.80 ALDH1A1 (0.56) ALDH1A1MAPTNPBWR1MEN1KMT2A
SCHEMBL594032 0.80 ALDH1A1 (0.56) ALDH1A1MAPTNPBWR1MEN1KMT2A
SCHEMBL833508 0.80 ALDH1A1 (0.77) ALDH1A1MAPTNPBWR1MEN1KMT2A
SCHEMBL31536798 0.80 ALDH1A1 (0.56) ALDH1A1MAPTNPBWR1MEN1KMT2A
SCHEMBL8260455 0.80 ALDH1A1 (0.56) ALDH1A1MAPTNPBWR1MEN1KMT2A
SCHEMBL23576776 0.80 PARP1 (0.51) ALDH1A1MAPTNPBWR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552770-B2 Compounds for treating respiratory disease TMEM16A LIMITED (GB) 2026-02-17 — — US disclosed
CN-119751456-A Spiro compounds C4医药公司 2025-04-04 — — CN disclosed
CN-112312904-B Spiro compounds C4医药公司 2025-01-07 — — CN disclosed
CN-114269721-B Compounds for the treatment of respiratory diseases TMEM16A有限公司 2024-12-20 — — CN disclosed
WO-2024219864-A1 NOVEL COMPOUND EXHIBITING SETDB1 INHIBITORY ACTIVITY, AND USE THEREOF 주식회사 넷타겟 2024-10-24 — — WO disclosed
CN-117466823-A Preparation method of one-pot 2- (4-aminophenyl) -5-aminobenzimidazole 天津众泰材料科技有限公司 2024-01-30 — — CN disclosed
US-20230416251-A1 SPIROCYCLIC COMPOUNDS C4 THERAPEUTICS, INC. (US) 2023-12-28 — — US disclosed
US-11584748-B2 Spirocyclic compounds C4 THERAPEUTICS, INC. (US) 2023-02-21 — — US disclosed
US-11447486-B2 2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin E synthase inhibitors INSTITUT PASTEUR KOREA (KR) 2022-09-20 — — US disclosed
EP-3983389-A1 COMPOUNDS FOR TREATING RESPIRATORY DISEASE TMEM16A LIMITED (GB) 2022-04-20 — — EP disclosed
US-5347008-A Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents CIBA-GEIGY CORPORATION (US) 1994-09-13 — — US disclosed
WO-1994008456-A1 POLYSUBSTITUTED BENZIMIDAZOLES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1994-04-28 — — WO disclosed
EP-0556334-A1 POLYSUBSTITUTED BENZIMIDAZOLES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1993-08-25 — — EP disclosed
US-5152929-A Corrosion inhibitors for water systems CIBA-GEIGY CORPORATION (US) 1992-10-06 — — US disclosed
US-5149700-A Antiarrhythmic agent AMERICAN HOME PRODUCTS CORPORATION (US) 1992-09-22 — — US disclosed
WO-1992007867-A1 POLYSUBSTITUTED BENZIMIDAZOLES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1992-05-14 — — WO disclosed
WO-1991018904-A1 SUBSTITUTED ARYLSULFONAMIDES AND BENZAMIDES AMERICAN HOME PRODUCTS CORPORATION (US) 1991-12-12 — — WO disclosed
US-4463173-A ANTIBIOTIC, BACTERICIDE ICI PHARMA (FR) 1984-07-31 — — US disclosed
EP-0031708-B1 CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES THEREFOR ICI PHARMA (FR) 1984-06-13 — — EP disclosed
EP-0031708-A2 Cephalosporin derivatives, processes for their manufacture, pharmaceutical compositions containing them and intermediates therefor ICI PHARMA (FR) 1981-07-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12552770-B2 Compounds for treating respiratory disease TMEM109, SCN1A, SLC16A1 ALDH1A1 596/4885MAPT 1158/4885NPBWR1 1277/4885
US-20230416251-A1 SPIROCYCLIC COMPOUNDS CRBN, RBX1, XIAP ALDH1A1 2000/4885MAPT 3398/4885NPBWR1 3556/4885
US-11447486-B2 2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin E synthase inhibitors ALOX5, ALOX15, ALOX12 ALDH1A1 582/4885MAPT 4695/4885NPBWR1 591/4885
US-11584748-B2 Spirocyclic compounds CRBN, RBX1, XIAP ALDH1A1 2000/4885MAPT 3398/4885NPBWR1 3556/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.