Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | CRHBP | P24387 | 1/20 | 0.65 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.65 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.65 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | CNR1 | P21554 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | HRH2 | P25021 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15412105 | 0.96 | HCAR3 (0.64) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL7972061 | 0.87 | MAPT (0.75) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL22382490 | 0.84 | MAPT (0.78) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL15412765 | 0.83 | LMNA (0.68) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL9043097 | 0.83 | MAPT (0.84) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL15413013 | 0.82 | LMNA (0.67) | MAPTALDH1A1RAB9APTGER4LMNA | |
| SCHEMBL15321333 | 0.82 | MAPT (0.82) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL15412512 | 0.81 | SCN1A (0.65) | MAPTALDH1A1RAB9APTGER4LMNA | |
| SCHEMBL9192588 | 0.81 | HCAR3 (0.77) | MAPTALDH1A1RAB9ANPC1PKM | |
| SCHEMBL9725412 | 0.81 | ALDH1A1 (0.63) | MAPTALDH1A1RAB9ANPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458102-B2 | Derivatives of tetracaine | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-10-04 | — | — | US | disclosed |
| US-9458102-B2 | Derivatives of tetracaine | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-10-04 | — | — | US | disclosed |
| US-9458102-B2 | Derivatives of tetracaine | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-10-04 | — | — | US | disclosed |
| US-20140018422-A1 | DERIVATIVES OF TETRACAINE | WILLAMETTE UNIVERSITY (US) | 2014-01-16 | — | — | US | disclosed |
| US-20140018422-A1 | DERIVATIVES OF TETRACAINE | WILLAMETTE UNIVERSITY (US) | 2014-01-16 | — | — | US | disclosed |
| US-20140018422-A1 | DERIVATIVES OF TETRACAINE | WILLAMETTE UNIVERSITY (US) | 2014-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018422-A1 | DERIVATIVES OF TETRACAINE | CACNA1G, CACNA1H, CACNA1I | MAPT 1590/4885ALDH1A1 3006/4885RAB9A 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.