Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235811 | 0.88 | KDM4E (0.48) | ACLYKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL15416657 | 0.85 | NUDT1 (0.36) | CCR2 | |
| SCHEMBL15416636 | 0.83 | NUDT1 (0.40) | — | |
| SCHEMBL16235734 | 0.82 | MEN1 (0.43) | ACLYKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL23301686 | 0.82 | CCR2 (0.55) | ACLYCCR2 | |
| SCHEMBL23330647 | 0.82 | ACLY (0.41) | ACLYCCR2 | |
| SCHEMBL31119628 | 0.81 | KDM4E (0.68) | ACLYKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL16235686 | 0.80 | ACLY (0.38) | ACLY | |
| SCHEMBL15416457 | 0.80 | — | — | |
| SCHEMBL15416321 | 0.80 | NOD2 (0.47) | KDM4EMEN1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872502-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014009302-A1 | NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2014-01-16 | — | — | WO | disclosed |