SCHEMBL15430481

SCHEMBL15430481

COC(=O)[C@H]1C[C@@H]1c1ccc(O)cc1

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DEGS1 O15121 1/20 0.50
SLC6A2 P23975 6/20 0.47
SLC6A4 P31645 5/20 0.47
ALDH1A1 P00352 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
SLC6A3 Q01959 4/20 0.44
IDO1 P14902 2/20 0.44
ATM Q13315 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16229142 1.00 DEGS1 (0.50) DEGS1SLC6A2SLC6A4ALDH1A1CYP1A2
SCHEMBL15430483 1.00 DEGS1 (0.50) DEGS1SLC6A2SLC6A4ALDH1A1CYP1A2
SCHEMBL1100407 1.00 DEGS1 (0.50) DEGS1SLC6A2SLC6A4ALDH1A1CYP1A2
SCHEMBL14097153 0.86 ALDH1A1 (0.63) SLC6A2SLC6A4ALDH1A1CYP1A2CYP3A4
SCHEMBL16585071 0.84 SLC6A3 (0.57) SLC6A2SLC6A4SLC6A3
SCHEMBL4718112 0.84 SLC6A4 (0.55) SLC6A2SLC6A4ALDH1A1CYP1A2CYP3A4
SCHEMBL4678571 0.84 SLC6A2 (0.46) SLC6A2SLC6A4ALDH1A1CYP1A2CYP3A4
SCHEMBL16585396 0.84 SLC6A4 (0.55) SLC6A2SLC6A4SLC6A3
SCHEMBL3970521 0.84 SLC6A4 (0.55) SLC6A2SLC6A4SLC6A3
SCHEMBL2359242 0.84 MAPT (0.56) SLC6A2SLC6A4ALDH1A1SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2855419-B1 NEW INDANYLOXYPHENYLCYCLOPROPANECARB OXYLIC ACIDS BOEHRINGER INGELHEIM INT (DE) 2017-03-01 EP disclosed
US-9308194-B2 Indanyloxyphenylcyclopropanecarboxylic acids BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2016-04-12 US disclosed
WO-2015078802-A1 NEW INDANYLOXYPHENYLCYCLOPROPANECARBOXYLIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-06-04 WO disclosed
US-20150148347-A1 INDANYLOXYPHENYLCYCLOPROPANECARBOXYLIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-05-28 US disclosed
US-8633182-B2 Indanyloxyphenylcyclopropanecarboxylic acids BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-01-21 US disclosed
WO-2013178575-A1 NEW INDANYLOXYPHENYLCYCLOPROPANECARB OXYLIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-12-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150148347-A1 INDANYLOXYPHENYLCYCLOPROPANECARBOXYLIC ACIDS GPR119, INSR, GPR65 DEGS1 1756/4885SLC6A2 3946/4885SLC6A4 3474/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.