SCHEMBL154332

SCHEMBL154332

c1ccc([SiH]([N][SiH](c2ccccc2)c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.35
TSHR P16473 4/20 0.32
DAO P14920 1/20 0.32
NAPRT Q6XQN6 1/20 0.32
LMNA P02545 2/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
CA1 P00915 2/20 0.30
CA2 P00918 2/20 0.30
CA9 Q16790 2/20 0.30
TDP1 Q9NUW8 2/20 0.30
CA12 O43570 1/20 0.30
GLA P06280 1/20 0.30
CA3 P07451 1/20 0.30
CA4 P22748 1/20 0.30
CA14 Q9ULX7 1/20 0.30
ALOX12 P18054 1/20 0.30
ACHE P22303 1/20 0.30
CA7 P43166 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL153206 0.73 ALDH1A1 (0.43) ALDH1A1TSHRLMNATDP1
SCHEMBL842865 0.69 LMNA (0.32) ALDH1A1LMNA
SCHEMBL7630769 0.68
Benzene SCHEMBL27873242 0.67 ALDH1A1 (0.40) ALDH1A1TSHRDAONAPRTLMNA
SCHEMBL38902 0.67 ALDH1A1 (0.40) ALDH1A1TSHRDAONAPRTLMNA
SCHEMBL3482296 0.67 ALDH1A1 (0.40) ALDH1A1TSHRDAONAPRTLMNA
SCHEMBL3202384 0.65
SCHEMBL10422510 0.65 ALDH1A1 (0.38) ALDH1A1TSHRDAONAPRTLMNA
Hydrochloric Acid SCHEMBL1400215 0.65 ALDH1A1 (0.38) ALDH1A1TSHRDAONAPRTLMNA
SCHEMBL38651919 0.65 ALDH1A1 (0.38) ALDH1A1TSHRDAONAPRTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2011526957-A 2011-10-20 JP claimed
EP-2307461-A1 POLYMERS FUNCTIONALIZED WITH IMIDE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP Bridgestone Corporation (JP) 2011-04-13 EP claimed
US-20100004414-A1 POLYMERS FUNCTIONALIZED WITH IMIDE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-01-07 US claimed
WO-2010002849-A1 POLYMERS FUNCTIONALIZED WITH IMIDE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-01-07 WO claimed
US-9884928-B2 Polymers functionalized with activated nitrogen heterocycles containing a pendant functional group BRIDGESTONE CORPORATION (JP) 2018-02-06 US disclosed
US-9738738-B2 Polymers functionalized with activated nitrogen heterocycles containing a pendant functional group BRIDGESTONE CORPORATION (JP) 2017-08-22 US disclosed
EP-2526149-B1 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORP (JP) 2017-03-01 EP disclosed
EP-2307461-B1 POLYMERS FUNCTIONALIZED WITH IMIDE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORP (JP) 2017-02-08 EP disclosed
US-9469706-B2 Polymers functionalized with unsaturated heterocycles containing a protected amino group BRIDGESTONE CORPORATION (JP) 2016-10-18 US disclosed
US-9469710-B2 Polymers functionalized with nitrile compounds containing a protected amino group BRIDGESTONE CORPORATION (JP) 2016-10-18 US disclosed
US-20160289355-A1 POLYMERS FUNCTIONALIZED WITH ACTIVATED NITROGEN HETEROCYCLES CONTAINING A PENDANT FUNCTIONAL GROUP BRIDGESTONE CORPORATION (JP) 2016-10-06 US disclosed
US-20160289354-A1 POLYMERS FUNCTIONALIZED WITH ACTIVATED NITROGEN HETEROCYCLES CONTAINING A PENDANT FUNCTIONAL GROUP BRIDGESTONE CORPORATION (JP) 2016-10-06 US disclosed
EP-2307461-A1 POLYMERS FUNCTIONALIZED WITH IMIDE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP Bridgestone Corporation (JP) 2011-04-13 EP disclosed
WO-2011041534-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-04-07 WO disclosed
US-20110077325-A1 FUNCTIONALIZED POLYMERS AND METHODS FOR THEIR MANUFACTURE BRIDGESTONE CORPORATION (JP) 2011-03-31 US disclosed
US-7906592-B2 Polymers functionalized with imide compounds containing a protected amino group BRIDGESTONE CORPORATION (JP) 2011-03-15 US disclosed
WO-2010085622-A9 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-12-23 WO disclosed
WO-2010085622-A2 POLYMERS FUNCTIONALIZED WITH NITRILE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-07-29 WO disclosed
US-20100004414-A1 POLYMERS FUNCTIONALIZED WITH IMIDE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-01-07 US disclosed
WO-2010002849-A1 POLYMERS FUNCTIONALIZED WITH IMIDE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP BRIDGESTONE CORPORATION (JP) 2010-01-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100004414-A1 POLYMERS FUNCTIONALIZED WITH IMIDE COMPOUNDS CONTAINING A PROTECTED AMINO GROUP PARG, PIN1, NPEPPS ALDH1A1 4339/4885TSHR 4416/4885DAO 209/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.