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Formocortal

Formocortal

SCHEMBL15438750

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nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Formocortal. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 13/20 0.57
▸ PGR P06401 6/20 0.57
▸ AR P10275 6/20 0.57
▸ HIF1A Q16665 5/20 0.57
▸ CYP3A4 P08684 3/20 0.57
▸ LMNA P02545 3/20 0.57
▸ ADORA3 P0DMS8 2/20 0.57
▸ ALDH1A1 P00352 2/20 0.57
▸ NR3C2 P08235 2/20 0.57
▸ NR1I2 O75469 1/20 0.57
▸ MEN1 O00255 1/20 0.57
▸ KMT2A Q03164 1/20 0.57
▸ CHRM1 P11229 1/20 0.50
▸ ADRA1A P35348 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.49
▸ CYP1A2 P05177 1/20 0.49
▸ CNR1 P21554 1/20 0.49
▸ PTGS1 P23219 1/20 0.49
▸ MAPT P10636 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6685138 0.82 NR3C1 (0.63) NR3C1PGRARHIF1ACYP3A4
Formocortal SCHEMBL4354 0.81 HIF1A (0.52) NR3C1PGRARHIF1ACYP3A4
Formocortal SCHEMBL21234455 0.81 HIF1A (0.52) NR3C1PGRARHIF1ACYP3A4
Formocortal SCHEMBL4353 0.81 HIF1A (0.52) NR3C1PGRARHIF1ACYP3A4
Formocortal SCHEMBL5484249 0.81 HIF1A (0.52) NR3C1PGRARHIF1ACYP3A4
Fluocinonide SCHEMBL28188734 0.79 PGR (0.70) NR3C1PGRARHIF1ACYP3A4
Fluticasone Propionate SCHEMBL4281973 0.78 NR3C1 (0.70) NR3C1PGRARHIF1ACYP3A4
Fluticasone Propionate SCHEMBL1692016 0.76 NR3C1 (0.67) NR3C1PGRARHIF1ACYP3A4
Fluticasone Propionate SCHEMBL15944858 0.76 NR3C1 (1.00) NR3C1PGRARHIF1ACYP3A4
Fluocinonide SCHEMBL13568069 0.76 HIF1A (1.00) NR3C1PGRARHIF1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140031281-A1 POLYMER-BASED SUSTAINED RELEASE DEVICE ALKERMES PHARMA IRELAND LIMITED (IE) 2014-01-30 — — US disclosed
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